国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (6): 403-406.

• 综述 •    下一篇

ABCG2介导的肿瘤多药耐药

沈菲, 陈宝安   

  1. 210009 南京，东南大学医学院中大医院血液科（江苏医学重点学科）
  • 出版日期:2013-06-08 发布日期:2013-05-24
  • 通讯作者: 陈宝安，E-mail: cba8888@hotmail.com E-mail:cba8888@hotmail.com
  • 基金资助:

    国家重点基础研究发展计划（973计划）项目（2010CB732404）

Multidrug resistance mediated by ABCG2

SHEN  Fei, CHEN  Bao-An   

  1. Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China
  • Online:2013-06-08 Published:2013-05-24
  • Contact: CHEN Bao-an E-mail:cba8888@hotmail.com

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摘要： ABCG2是ATP结合盒（ABC）转运超家族中的一员，其过表达被认为是限制多种化疗药物在细胞内聚集的重要机制之一。ABCG2底物范围广泛，包括多种抗肿瘤药物和环境致癌物等，与肿瘤的多药耐药（MDR）和肿瘤发展有关。以ABCG2为靶点逆转MDR受到广泛关注。

关键词: font-size: 12pt, mso-bidi-font-family: 'Times New Roman', mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA">肿瘤, 抗药性, 多药, 人ABCG2蛋白

Abstract: ABCG2 is a member of the ATP-binding cassette (ABC) transporter family. The overexpression of ABCG2 is identified as one of the important mechanisms that limiting cellular accumulation of various compounds. With regard to its broad substrate spectrum including various anticancer drugs and environmental carcinogens, the function of ABCG2 is associated with multidrug resistance (MDR) and tumor development. ABCG2 as a target site to reverse MDR has been widely concered.

Key words: Neoplasms, Drug resistance, multiple, ABCG2 protein, human