国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (2): 153-156.

• 论著 • 上一篇    下一篇

乳腺导管原位癌患者生活质量调查及相关因素分析

蒋蓓琦, 傅韵, 武弈, 成小林, 李正东, 庄志刚   

  1. 200040 上海，同济大学附属第一妇婴保健院乳腺外科
  • 出版日期:2013-02-08 发布日期:2013-01-25
  • 通讯作者: 庄志刚，E-mail：zhuang_zg@163.com E-mail:zhuang_zg@163.com

Survey of quality of life for patients with breast ductal carcinoma in situ and analysis of related factors

JIANG  Bei-Qi, FU  Yun, WU  Yi, CHENG  Xiao-Lin, LI  Zheng-Dong, ZHUANG  Zhi-Gang   

  1. Department of Breast Surgery,Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, China
  • Online:2013-02-08 Published:2013-01-25
  • Contact: Corresponding author: ZHUANG Zhi-gang, E-mail: zhuang_zg@163.com E-mail:zhuang_zg@163.com

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1569

被引次数

25

摘要： 目的 调查乳腺导管原位癌（DCIS）患者生活质量（QOL），分析相关影响因素。方法  采用36 条目简明量表（SF-36），对术后1年的84 例DCIS患者、125例浸润性乳腺癌患者进行QOL评估，分析年龄、手术方式、内分泌治疗、学历、婚姻状况、工作状态、医疗保险对患者QOL的影响。结果  与正常女性相比，术后1年的DCIS患者在生理功能（P=0.029）、躯体疼痛（P=0.039）、总体健康（P=0.033）和精神健康（P=0.003）4个维度得分较低，而浸润性乳腺癌患者在生理功能（P=0.002）、躯体疼痛（P=0.002）、活力（P=0.002）、总体健康（P=0.002）和精神健康（P=0.001）5个维度得分低于正常。两组患者QOL大致相似，有6个维度得分无显著性差异，但在生理功能（P=0.032）和活力（P=0.040）方面DCIS患者优于浸润性癌患者。术后内分泌治疗是影响DCIS患者QOL的重要因素，显著降低了患者生理功能（P=0.034）、躯体疼痛（P=0.046）、总体健康（P=0.031）、活力（P=0.042）和精神健康（P=0.002）5个维度得分。结论  术后1年DCIS患者QOL较差，内分泌治疗是重要影响因素。

关键词: 乳腺肿瘤, 癌, 导管内, 非浸润性, 生活质量, 36条目简明量表

Abstract: Objective To study the quality of life (QOL) of patientswith ductal carcinoma in situ (DCIS) and to analyze the relevant factors affecting their QOL. Methods A total of 84 patients with DCIS and 125 patients with invasive breast cancer were surveyed. Researchers used SF-36 to assess the QOL of participants at one year after operation. Some information of patients were analyzed the relationship to SF-36 score, such as age, the type of surgery, endocrine therapy, education, marital status, working status and health insurance. Results Compared to normal women, patients with DCIS had lower QOL in physical function (P=0.029), bodily pain (P=0.039), general health (P=0.033) and mental health (P=0.003). Patients with invasive breast cancer also had poorer QOL in physical function (P=0.002), bodily pain (P=0.002), vitality (P=0.002), general health (P=0.002) and mental health (P=0.001). QOL of DCIS patients were similar to that of invasive breast cancer patients, except that score of physical function (P=0.032) and vitality (P=0.040) were better in DCIS patients. Endocrine therapy significantly affected the score of QOL of DCIS patients. DCIS patients with endocrine therapy had poorer score in physical function (P=0.034), bodily pain (P=0.046), general health (P=0.031), vitality (P=0.042) and mental health (P=0.002). Conclusion Patients with DCIS have poor QOL at one year after operation. Endocrine therapy significantly reduces their QOL.

Key words: Breast neoplasms, Carcinoma, intraductal, noninfiltrating, Quality of life, SF-36