国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (2): 134-137.

• 综述 • 上一篇    下一篇

胃癌癌前病变相关标志物的检测

刘中娟, 程歆琦, 郭子建, 赵丽娜, 邱玲   

  1. 100730 北京，  中国医学科学院 中国协和医科大学 北京协和医院检验科
  • 出版日期:2013-02-08 发布日期:2013-01-25
  • 通讯作者: 邱玲，E-mail: lingqiubj@yahoo.com.cn E-mail:lingqiubj@yahoo.com.cn

Detection of the tumor markers in patients with gastric precancerous lesions

LIU  Zhong-Juan, CHENG  Xin-Qi, GUO  Zi-Jian, ZHAO  Li-Na, QIU  Ling   

  1. Department of Laboratory Medicine, Peking Union Medical College Hospital, CAMS and PUMC, Beijing 100730, China 
  • Online:2013-02-08 Published:2013-01-25
  • Contact: Corresponding author: QIU Ling, E-mail: lingqiubj@yahoo.com.cn E-mail:lingqiubj@yahoo.com.cn

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1505

被引次数

10

摘要： 目前的研究证实，幽门螺旋杆菌感染引起的慢性萎缩性胃炎是诱发胃癌的主要癌前病变，是胃癌风险评估的关键并影响胃蛋白酶原（PG）和胃泌素-17（G-17）分泌。大多数胃癌患者预后差，且缺乏非侵袭性的筛查和诊断手段，因此早期发现胃癌以降低胃癌死亡率非常必要。PG和G-17分别为胃体黏膜和胃窦的生物标记物，这些特异性生物标记物的检测为了解肿瘤发生前胃黏膜的状况提供了可能。

关键词: 胃肿瘤, 胃炎, 萎缩性, 胃蛋白酶原A, 胃蛋白酶原B, 胃泌素类, 螺杆菌, 幽门

Abstract: It is confirmed that chronic atrophic gastritis (CAG) which is caused by Helicobacter pylori is the main cause of gastric precancerous lesions. CAG is also the key determinant in gastric cancer risk assessment, which affects pepsinogen and gastrin-17 secretion. Most of the gastric cancer patients with poor prognosis, and non-invasive tools for gastric cancer screening and diagnosis are lacking. Therefore, the early detection of gastric cancer in order to reduce the disease mortality is necessary. Pepsinogen and gastrin-17 are biomarkers of gastric mucosa and gastric antra. The serological testing for the stomach-specific biomarkers offers the possibility to know preneoplastic gastric mucosal conditions.

Key words: Stomach neoplasms, Gastritis, atrophic, Pepsinogen A, Pepsinogen B, Gastrins, Helicobacter pylori