国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (2): 86-89.

• 综述 • 上一篇    下一篇

硫氧还蛋白相关蛋白14的研究

傅志勤, 谢幸, 程晓东   

  1. 310006 杭州，浙江大学医学院附属妇产科医院（傅志勤，谢幸，程晓东）
  • 出版日期:2013-02-08 发布日期:2013-01-25
  • 通讯作者: 谢幸，E-mail: xiex@mail.hz.zj.cn E-mail:xiex@mail.hz.zj.cn
  • 基金资助:

    国家自然科学基金（81072119）

Research progress of thioredoxin-related protein 14

FU  Zhi-Qin, XIE  Xing, CHENG  Xiao-Dong   

  1. Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
  • Online:2013-02-08 Published:2013-01-25
  • Contact: Corresponding author: XIE Xing, E-mail: xiex@mail.hz.zj.cn E-mail:xiex@mail.hz.zj.cn

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摘要：     硫氧还蛋白相关蛋白14（TRP14）是一种新发现的硫氧还蛋白（Trx）家族二硫还原酶，具有保守的CPDC模序。其结构和功能既与Trx家族代表性成员Trx具有相似性，又有诸多不同。当肿瘤坏死因子-α（TNF-α）诱导细胞产生活性氧时，TRP14可作为细胞内氧化还原状态的感受器，改变其作用底物动力蛋白轻链的氧化状态，从而调控TNF-α诱导的转录核因子-κB（NF-κB）信号途径，丝裂原活化的蛋白激酶信号途径和凋亡信号途径。

关键词: 硫氧还原蛋白质类, 肿瘤坏死因子-α, 硫氧相关还原蛋白14

Abstract: Thioredoxin-related protein 14 (TRP14), a new member of Trx family, is a novel disulfide reductase with conservative CPDC motif. Its structure and function are comparable to Trx, which is the representative member of Trx family. However, there are many differences. When tumor necrosis factor-α (TNF-α) induced cells to produce the active oxygen, TRP14 can as a sensor of the intracellular redox state, change oxidation state of dynein lifht chain (its substrate), thereby regulate NF-κB signaling pathways induced by TNF-α, MAPK and apoptosis signaling pathways.

Key words: Thioredoxins, Tumor necrosis factor-alpha, Thioredoxin-related protein 14