国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (4): 292-295.

• 综述 • 上一篇    下一篇

表观遗传调控与胃癌

陈济, 刘定义   

  1. 610041 成都市第七人民医院 成都市肿瘤医院肿瘤科
  • 出版日期:2012-04-08 发布日期:2012-03-28
  • 通讯作者: 刘定义，E-mail: chenji-158@163.com E-mail:chenji-158@163.com

Epigenetic regulation and gastric cancer

CHEN  Ji, LIU  Ding-Yi   

  1. Department of Oncology, Chengdu Cancer Hospital, Seventh People’s Hospital Chengdu, Chengdu 610041, China
  • Online:2012-04-08 Published:2012-03-28
  • Contact: Corresponding author: LIU Ding-yi, E-mail: chenji-158@163.com E-mail:chenji-158@163.com

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被引次数

3

摘要： 胃癌的发生是机体内外环境因素共同影响的结果。研究表明，外界环境因素通过DNA甲基化和（或）去甲基化修饰，组蛋白修饰及小分子RNA等表观遗传学修饰途径调控细胞生长、发育过程中关键基因的表达变化，从而在胃癌的发生及发展过程中发挥重要作用。

关键词: 胃肿瘤, 后成说, 遗传, DNA甲基化, 组蛋白密码, 微RNAs

Abstract: The initiation and development of gastric cancer is due to the effects from both external and internal factors. Recent researches show that external environment factors regulate and control the key genes expression during the process of cell’s growth and development through epigenetic modification such as DNA methylation or demethylation, histone modification and small RNA, thus playing an important role in gastric cancer’s occurrence and development.

Key words: Stomach neoplasms, Epigenesis, genetic, DNA methylation, Histone code, MicroRNAs