国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (4): 262-264.

• 综述 • 上一篇    下一篇

恶性脑胶质瘤的治疗

肖锋, 王洪林, 李云海   

  1. 200240 上海,复旦大学附属肿瘤医院闵行分院
  • 出版日期:2012-04-08 发布日期:2012-03-28
  • 通讯作者: 王洪林,E-mail: honglin-wang@sohu.com E-mail:honglin-wang@sohu.com

Therapy for malignant glioma

XIAO  Feng, WANG  Hong-Lin, LI  Yun-Hai   

  1. Minhang Branch of Cancer Hospital, Fudan University, Shanghai, 200240, China
  • Online:2012-04-08 Published:2012-03-28
  • Contact: WANG Hong-Lin,E-mail: honglin-wang@sohu.com E-mail:honglin-wang@sohu.com

摘要: 恶性脑胶质瘤的治疗方法包括手术、放疗、化疗,但总体疗效不佳。近年来替莫唑胺的应用,总体有效率比以往的化疗药物好,但仍有部分耐药;血管生成抑制剂显示出有希望的前景,但价格昂贵;塞来昔布具有抗血管生成活性,可能成为恶性脑胶质瘤新的治疗选择。

关键词: 神经胶质瘤, 血管生成抑制剂, 替莫唑胺, 塞来昔布

Abstract: Therapies for malignant glioma include surgery, radiotherapy and chemotherapy. In recent years, the overall effective rate of temozolomide is better than other chemotherapy drugs, but partly patients have resistance to temozolomide. Angiogenesis inhibitors show promising activity, but it is expensive. Celecoxib has antiangiogenic activity, which has become a new option.

Key words: Glioma, Angiogenesis inhibitors, Temozolomide, Celecoxib