国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (3): 220-222.

• 综述 • 上一篇    下一篇

高迁移率蛋白B1与胃癌

袁海滨, 王东旭, 陈小庆   

  1. 300142 天津，解放军254医院消化内科
  • 出版日期:2012-03-08 发布日期:2012-02-24

HMGB1 and gastric cancer

YUAN  Hai-Bin, WANG  Dong-Xu, CHEN  Xiao-Qing   

  1. Department of Gastroenterology, the 254 Hospital of PLA, Tianjin 300142, China

  • Online:2012-03-08 Published:2012-02-24

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摘要： 高迁移率蛋白1(HMGB1)是一种非组核蛋白，正常情况下，作为细胞核内染色质的组分之一，调节基因的转录、重组、修复等生命活动。在胞外，HMGB1参与细胞的增殖、分化、迁移及神经轴突的生长。研究发现HMGB1与多种肿瘤如肺癌、结肠癌、胰腺癌等的发生发展、浸润转移等生物学行为关系密切。关于HMGB1与胃癌相关性的研究对于胃癌的早期诊断与治疗价值很大。

关键词: color: black, font-family: 宋体, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-bidi-font-family: 'Times New Roman'">胃肿瘤, 免疫组织化学, 高迁移率族蛋白-1

Abstract: High mobility group box-1 (HMGB1) is a nonhistone nuclear protein. Normally, as one component of the chromatin, HMGB1 regulate life activities such as genetic transcription, recombination and gene repair. HMGB1 can be realeased to the outside of the cell, which can be bound up with cells multiplication, differentiation, migration and the growth of nerve axon. Studies show that HMGB1 is correlated with tumor’s occurrence, development, invasion and metastasis, such as lung cancer, colorectal cancer, pancreatic cancer and so on. The studies about the relativity between HMGB1 and gastric cancer play an important role in the diagnosis and treatment of gastric cancers.

Key words: Gastric neoplasms, Immunohisto-chemistry, High mobility group box B1