国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (3): 222-224.

• 综述 • 上一篇    下一篇

哺乳动物雷帕霉素靶蛋白在胃癌的研究进展

陈小庆, 王东旭, 袁海滨   

  1. 300142  天津, 解放军254医院消化内科
  • 出版日期:2012-03-08 发布日期:2012-02-24

Mammalian target of rapamycin in gastric cancer

CHEN  Xiao-Qing, WANG  Dong-Xu, YUAN  Hai-Bin   

  1. Department of Gastroenterology, the 254 Hospital of PLA, Tianjin 300142, China

  • Online:2012-03-08 Published:2012-02-24

摘要： 哺乳动物雷帕霉素靶蛋白(mTOR)在调节细胞增殖、生长、能量代谢等方面起重要作用,在很多肿瘤中表达过量，通过mTOR抑制剂雷帕霉素等可以起到抑制胃癌发展的作用。联合mTOR上下游通路研究对胃癌的早期诊断、监测疗效及预后价值更大。

关键词: color: green, font-size: 12pt, mso-font-kerning: 1.0pt, mso-bidi-font-family: 'Times New Roman', mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA">胃肿瘤, 哺乳动物雷帕霉素靶蛋白

Abstract: Mammalian target of rapamycin (mTOR) plays an important role in the regulation of cell proliferation, growth, energy metabolism and so on. Clinical research demonstrate that many tumors have its excessive expression, and the mTOR inhibitors rapamycin can resist the development of gastric cancer. In recent years, research of mTOR signaling pathway combined with its upstream and downstream has larger value for the early diagnosis, monitoring curative effect and prognosis.

Key words: color: green, font-size: 12pt, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体" lang="EN-US">Gastric neoplasms, color: green, font-size: 12pt, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体" lang="EN-US">Mammalian target of rapamycin