侵袭性伪足在肿瘤转移中的作用机制与治疗转化前沿

doi:10.3760/cma.j.cn371439-20251009-00015

摘要/Abstract

摘要：

侵袭性伪足是肿瘤细胞降解细胞外基质、促进局部浸润与远端转移的核心亚细胞结构。近年研究不仅解析了其分子组成与动态组装机制，更逐步揭示其在整合肿瘤微环境信号、介导癌种间调控异质性中的枢纽作用。值得注意的是，放疗或化疗等治疗应激可能意外激活侵袭性伪足，进而推动肿瘤适应性抵抗的形成。针对该结构，靶向其支架蛋白、蛋白酶递送系统及细胞外囊泡通讯等多维干预策略逐渐兴起，结合药物重定位与纳米精准递送等技术，可为开发新型抗转移疗法提供重要理论基础与转化方向。

关键词: 足体, 肿瘤转移, 肿瘤微环境, 基质金属蛋白酶类, 分子靶向治疗

Abstract:

Invadopodia are core subcellular structures in which tumor cells degrade extracellular matrix， drive local infiltration and distant metastasis. Recent studies have not only analyzed the molecular composition and dynamic assembly mechanisms， but also gradually revealed their central role as hubs in integrating tumor microenvironment signals and mediating regulatory heterogeneity across cancer types. It is noteworthy that therapeutic interventions such as radiotherapy or chemotherapy may inadvertently induce the activation of invadopodia， thus contributing to the development of tumor adaptive resistance. In response， multi-dimensional intervention strategies targeting invadopodial scaffold proteins， protease delivery systems， and extracellular vesicle-mediated communication are gaining momentum. Coupled with drug repositioning and precision nanodelivery technologies， these approaches can provide important theoretical basis and translation direction for the development of next-generation anti-metastatic therapies.

Key words: Podosomes, Neoplasm metastasis, Tumor microenvironment, Matrix metalloproteinases, Molecular targeted therapy

张龙, 李建振, 张伟. 侵袭性伪足在肿瘤转移中的作用机制与治疗转化前沿[J]. 国际肿瘤学杂志, 2026, 53(2): 100-104.

Zhang Long, Li Jianzhen, Zhang Wei. Mechanisms of invadopodia in tumor metastasis and frontiers in therapeutic translation[J]. Journal of International Oncology, 2026, 53(2): 100-104.

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