国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (2): 113-116.doi: 10.3760/cma.j.issn.1673-422X.2019.02.012

• 综述 • 上一篇    下一篇

老年性食管癌放疗进展

廖烨,赵丽娜,石梅   

  1. 中国人民解放军空军军医大学第一附属医院放射治疗科,西安710032
  • 出版日期:2019-02-08 发布日期:2019-04-03
  • 通讯作者: 廖烨,Email: 1758850481@qq.com E-mail:1758850481@qq.com

Radiotherapy for elderly esophageal cancer

Liao Ye, Zhao Lina, Shi Mei   

  1. Department of Radiotherapy, First Affiliated Hospital of Fourth Military Medical University, Xi′an 710032, China
  • Online:2019-02-08 Published:2019-04-03
  • Contact: Liao Ye, Email: 1758850481@qq.com E-mail:1758850481@qq.com

摘要: 对于可切除的老年食管癌,在充分衡量患者身体机能状态的情况下,新辅助放化疗联合手术仍是首选的治疗手段。根治性放化疗是无法手术的食管癌患者的首选治疗方式,对于肿瘤消退反应良好的老年可手术患者可能也是一种很好的替代方法。而对于更高龄患者(>80岁),温和保守的单纯放疗或许是更理想的选择。同时,相比于常规照射剂量(50.4 Gy)、选择性淋巴结区域照射、标准PF方案(顺铂+5氟尿嘧啶),高剂量(≥60 Gy)、累及野照射的放疗联合单药化疗(如替吉奥)可能会带来更好的预后。

关键词: 食管肿瘤, 放射疗法, 肿瘤辅助疗法, 放射治疗剂量, 根治性同步放化疗

Abstract: For resectable elderly esophageal cancer, neoadjuvant chemoradiotherapy combined with surgery is still the preferred treatment under the condition of fully measuring the patient′s physical function. Definitive chemoradiation is the first choice for patients with inoperable esophageal cancer, and may be a good alternative for elderly operable patients with good response to tumor regression. For older patients (>80 years old), radiotherapy alone may be mild and conservative enough to be the preferred option. At the same time, compared with conventional radiation dose (50.4 Gy), selective regional lymph node irradiation, standard PF regimen (cisplatin + 5fluorouracil), radiotherapy of high dose (≥60 Gy), involving field irradiation combined with singledrug chemotherapy (such as tegio) can bring better prognosis.

Key words: Esophageal neoplasms, Radiotherapy, Neoadjuvant therapy, Radiotherapy dosage, Definitive chemoradiation