微小RNA与食管鳞状细胞癌

doi:10.3760/cma.j.issn.1673-422X.2016.11.015

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (11): 858-860.doi: 10.3760/cma.j.issn.1673-422X.2016.11.015

微小RNA与食管鳞状细胞癌

陈俊，李杰

030013 太原，山西医科大学附属肿瘤医院放疗胸科一病区

收稿日期:2016-02-03 出版日期:2016-11-08 发布日期:2016-11-02
通讯作者: 李杰，Email: lijie942003@163.com E-mail:lijie942003@163.com

MicroRNAs and esophageal squamous cell carcinoma

Chen Jun, Li Jie

First Ward of Department of Thoracic Radiotherapy, Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan 030013, China

Received:2016-02-03 Online:2016-11-08 Published:2016-11-02
Contact: Li Jie E-mail:lijie942003@163.com

摘要/Abstract

摘要： 微小RNA(miRNA)可通过细胞信号转导、上皮间质转化、血管生成等调控机制影响食管鳞状细胞癌细胞的增殖、凋亡、侵袭和转移。特定的血清miRNA可作为食管鳞状细胞癌诊断、预后的新型肿瘤标志物。近来研究表明miRNA可提高食管鳞状细胞癌放疗敏感性甚至逆转多药耐药，具有极大的临床价值。

关键词: 微RNAs, 食管肿瘤

Abstract: MicroRNAs (miRNAs) can influence the proliferation, apoptosis, invasion and metastasis of esophageal squamous cell carcinoma (ESCC) cells by signal transduction, epithelialmesenchymal transition, angiogenesis and other regulating mechanisms. Specific serum miRNAs can serve as novel diagnostic and prognostic biomarkers of ESCC. Recent studies have indicated that miRNAs can improve the radiation sensitivity and even reverse multidrug resistance of ESCC, holding great clinical value.

Key words: MicroRNAs, Esophageal neoplasms

陈俊，李杰. 微小RNA与食管鳞状细胞癌[J]. 国际肿瘤学杂志, 2016, 43(11): 858-860.

Chen Jun, Li Jie. MicroRNAs and esophageal squamous cell carcinoma[J]. Journal of International Oncology, 2016, 43(11): 858-860.

参考文献

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微小RNA与食管鳞状细胞癌

MicroRNAs and esophageal squamous cell carcinoma

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