外周T细胞淋巴瘤靶向治疗的研究进展

doi:10.3760/cma.j.cn371439-20260315-00109

摘要/Abstract

摘要：

外周T细胞淋巴瘤（PTCL）是一组起源于胸腺后成熟T细胞和自然杀伤细胞的异质性较大的恶性肿瘤，包括多种亚型，几乎均呈现高度侵袭性。目前，PTCL患者的一线治疗仍遵循侵袭性B细胞淋巴瘤的治疗方案，但疗效持续时间短且不良反应严重，患者总体5年生存率仅约30%，预后不良。近年来，随着分子遗传学与表观遗传学的发展，新型靶向药物不断涌现并在各类临床研究中表现出了良好的疗效和安全性，新药联合治疗还有望突破单药疗效瓶颈。对PTCL临床靶向治疗目前的最新研究进展及临床前景进行探讨与总结，可为PTCL靶向治疗的临床决策提供依据。

关键词: 淋巴瘤, T细胞, 外周, 分子靶向治疗, 临床试验

Abstract:

Peripheral T-cell lymphoma （PTCL） is a heterogeneous group of malignant tumors originating from post-thymic mature T cells and natural killer cells， encompassing multiple subtypes， almost all of which exhibit high aggressiveness. Currently， the first-line treatment for PTCL patients still follows the therapeutic regimen for aggressive B-cell lymphoma， but the efficacy duration is short and the adverse effects are severe， with an overall 5-year survival rate of only approximately 30%， indicating a poor prognosis. In recent years， with the advancement of molecular genetics and epigenetics， novel targeted drugs have emerged continuously and demonstrated good efficacy and safety profile in various clinical studies. Combination therapies of new drugs are expected to overcome the efficacy limitations of monotherapy. To explore and summarize the latest research progress and clinical prospects of targeted therapy for PTCL， which can provide a basis for clinical decision-making of targeted therapy for PTCL.

Key words: Lymphoma, T-cell, peripheral, Molecular targeted therapy, Clinical trial

韩明明, 乔琪琪, 殷霞, 邢立杰, 刘丹. 外周T细胞淋巴瘤靶向治疗的研究进展[J]. 国际肿瘤学杂志, 2026, 53(11): 699-704.

Han Mingming, Qiao Qiqi, Yin Xia, Xing Lijie, Liu Dan. Research progress in targeted therapy for peripheral T-cell lymphoma[J]. Journal of International Oncology, 2026, 53(11): 699-704.

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