非小细胞肺癌中cGAS-STING信号通路的作用机制及其靶向治疗策略

doi:10.3760/cma.j.cn371439-20250415-00099

摘要/Abstract

摘要：

非小细胞肺癌（NSCLC）的治疗因肿瘤异质性与免疫微环境的复杂性面临严峻挑战，环鸟苷酸-腺苷酸合成酶（cGAS）-干扰素基因刺激因子（STING）信号通路在NSCLC中具有双重作用，其既是抗肿瘤免疫的关键枢纽，也是潜在转移驱动因子。STING激动剂临床转化面临一系列挑战，如递送障碍、双刃剑效应、患者异质性等，探索STING激动剂与放化疗、免疫检查点抑制剂、新型免疫疗法的联合应用以及利用人工智能多组学模型实现个体化预测与治疗意义重大。深入解析cGAS-STING信号通路的分子调控网络及其在肿瘤微环境中的动态作用，对于克服目前靶向治疗的临床挑战、推动NSCLC免疫治疗策略的精准化发展具有重要意义。

关键词: 癌，非小细胞肺, 肿瘤微环境, 治疗, cGAS-STING信号通路

Abstract:

The treatment of non-small cell lung cancer （NSCLC） faces significant challenges due to tumor heterogeneity and the complexity of the immune microenvironment. The cyclic GMP-AMP synthase （cGAS）-stimulator of interferon gene （STING） signaling pathway plays a dual role in NSCLC， serving both as a crucial hub for anti-tumor immunity and as a potential driver of metastasis. The clinical translation of STING agonists confronts a series of challenges， including delivery barriers， double-edged sword effects， and patient heterogeneity. Consequently， exploring the combined application of STING agonists with radiotherapy/chemotherapy， immune checkpoint inhibitors， and novel immunotherapies， alongside leveraging artificial intelligence-driven multi-omics models for individualized prediction and treatment， holds significant importance. A deeper understanding of the molecular regulatory network of the cGAS-STING signaling pathway and its dynamic functions within the tumor microenvironment is essential for overcoming the current clinical challenges of targeted therapies and advancing the precision development of NSCLC immunotherapy strategies.

Key words: Carcinoma， non-small-cell lung, Tumor microenvironment, Therapy, cGAS-STING pathway

澈根, 乌日汗, 朱恬恬, 东丽. 非小细胞肺癌中cGAS-STING信号通路的作用机制及其靶向治疗策略[J]. 国际肿瘤学杂志, 2025, 52(9): 587-591.

Che Gen, Wu Rihan, Zhu Tiantian, Dong Li. Mechanism of the cGAS-STING signaling pathway in non-small cell lung cancer and its targeted therapeutic strategies[J]. Journal of International Oncology, 2025, 52(9): 587-591.

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