长非编码RNA GHET1在消化系统肿瘤中的作用机制

doi:10.3760/cma.j.cn371439-20200209-00024

摘要/Abstract

摘要：

胃癌高表达转录本1(GHET1)首先在胃癌组织中被发现,是一种长非编码RNA(lncRNA)。GHET1定位于染色体7q36.1,高表达于多种肿瘤中,并且GHET1的高表达与不良预后密切相关。研究发现,GHET1通过与微小RNA(miRNA)或蛋白相互作用参与调控机体的诸多生理病理过程,尤其在消化系统肿瘤中起重要调控作用,将来有望成为有价值的肿瘤标志物和治疗靶点。

关键词: RNA,长链非编码, 消化系统肿瘤, 胃癌高表达转录本1

Abstract:

Gastric cancer highly expressed transcript 1 (GHET1) is first found in gastric cancer and is a long non-coding RNA (lncRNA). GHET1 is located on chromosome 7q36.1, and is highly expressed in many tumors. High expression of GHET1 is closely related to poor prognosis. Studies have found that GHET1 is involved in regulating many physiological and pathological processes of the body through interaction with microRNAs (miRNAs) or proteins, especially in digestive system tumors, and is expected to become a valuable tumor marker and therapeutic target in the future.

Key words: RNA,long noncoding, Digestive system neoplasms, Gastric cancer highly expressed transcript 1

马英骥, 孙丽斌, 邱文生. 长非编码RNA GHET1在消化系统肿瘤中的作用机制[J]. 国际肿瘤学杂志, 2020, 47(5): 304-307.

Ma Yingji, Sun Libin, Qiu Wensheng. Mechanism of long non-coding RNA GHET1 in tumors of the digestive system[J]. Journal of International Oncology, 2020, 47(5): 304-307.

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