非小细胞肺癌放射敏感性标志物

doi:10.3760/cma.j.cn371439-20190923-00009

国际肿瘤学杂志 ›› 2020, Vol. 47 ›› Issue (4): 236-239.doi: 10.3760/cma.j.cn371439-20190923-00009

非小细胞肺癌放射敏感性标志物

李光烈¹, 阎英²()

¹ 大连医科大学研究生院 116044
² 北部战区总医院放射治疗科,沈阳 110000

收稿日期:2019-09-23 修回日期:2019-10-27 出版日期:2020-04-08 发布日期:2020-05-26
通讯作者: 阎英 E-mail:yanyingdoctor@sina.com
基金资助:
辽宁省科技重大专项计划(2019040060-JH1/103-05)

Radiosensitivity markers of non-small cell lung cancer

Li Guanglie¹, Yan Ying²()

¹ Graduate School, Dalian Medical University, Dalian 116044, China
² Department of Radiotherapy, General Hospital of Northern War Zone, Shenyang 110000, China

Received:2019-09-23 Revised:2019-10-27 Online:2020-04-08 Published:2020-05-26
Contact: Yan Ying E-mail:yanyingdoctor@sina.com
Supported by:
Major Science and Technology Project of Liaoning Province of China(2019040060-JH1/103-05)

摘要/Abstract

摘要：

对于非小细胞肺癌患者的治疗而言,放疗是重要的局部治疗方法之一。但治疗过程中出现的放疗抵抗往往是影响疗效的最大障碍,也是治疗失败的主要原因。寻找放射敏感性标志物,对于发现其具体抵抗机制,改善疗效及预后有重大的意义,并可为非小细胞肺癌的放射增敏治疗提供思路及依据。

关键词: 癌,非小细胞肺, 辐射耐受性, 蛋白质类, RNA,长链非编码, 微RNAs

Abstract:

Radiotherapy is one of the important local treatments for patients with non-small cell lung cancer. However, radiotherapy is often the biggest obstacle to the curative effect and the main cause of treatment failure. Looking for radiosensitivity markers is of great significance to discover specific resistance mechanism, improve efficacy and prognosis, and provide ideas and basis for radiosensitization treatment of non-small cell lung cancer.

Key words: Carcinoma,non-small-cell lung, Radiation tolerance, Proteins, RNA,long noncoding, MicroRNAs

李光烈, 阎英. 非小细胞肺癌放射敏感性标志物[J]. 国际肿瘤学杂志, 2020, 47(4): 236-239.

Li Guanglie, Yan Ying. Radiosensitivity markers of non-small cell lung cancer[J]. Journal of International Oncology, 2020, 47(4): 236-239.

参考文献 30

[1]	Chen W, Zheng R, Baade PD , et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016,66(2):115-132. DOI: 10.3322/caac.21338. doi: 10.3322/caac.21338
[2]	Siegel RL, Miller KD, Jemal A . Cancer statistics, 2015[J]. CA Cancer J Clin, 2015,65(1):5-29. DOI: 10.3322/caac.21254. doi: 10.3322/caac.21254
[3]	Murugan AK. mTOR: Role in cancer, metastasis and drug resistance[J]. Semin Cancer Biol, 2019, pii: S1044-579X(18) 30135-4. DOI: 10.1016/j.semcancer.2019.07.003.
[4]	Chen Y, Li W, Peng P , et al. mTORC1 inhibitor RAD001 (everolimus) enhances non-small cell lung cancer cell radiosensitivity in vitro via suppressing epithelial-mesenchymal transition[J]. Acta Pharmacol Sin, 2019,40(8):1085-1094. DOI: 10.1038/s41401-019-0215-y. doi: 10.1038/s41401-019-0215-y
[5]	Zhao L, Wang DL, Liu Y , et al. Histone acetyltransferase hMOF promotes S phase entry and tumorigenesis in lung cancer[J]. Cell Signal, 2013,25(8):1689-1698. DOI: 10.1016/j.cellsig.2013.04.006. doi: 10.1016/j.cellsig.2013.04.006
[6]	Li N, Tian GW, Tang LR , et al. hMOF reduction enhances radiosensitivity through the homologous recombination pathway in non-small-cell lung cancer[J]. Onco Targets Ther, 2019,12:3065-3075. DOI: 10.2147/OTT.S192568. doi: 10.2147/OTT
[7]	Torok JA, Oh P, Castle KD , et al. Deletion of Atm in tumor but not endothelial cells improves radiation response in a primary mouse model of lung adenocarcinoma[J]. Cancer Res, 2019,79(4):773-782. DOI: 10.1158/0008-5472.CAN-17-3103. doi: 10.1158/0008-5472.CAN-17-3103
[8]	Zhong X, Luo G, Zhou X , et al. Rad51 in regulating the radiosensitivity of non-small cell lung cancer with different epidermal growth factor receptor mutation status[J]. Thoracic Cancer, 2016,7(1):50-60. DOI: 10.1111/1759-7714.12274. doi: 10.1111/1759-7714.12274
[9]	Yin ZJ, Jin FG, Liu TG , et al. Overexpression of STAT3 potentiates growth, survival, and radioresistance of non-small-cell lung cancer (NSCLC) cells[J]. J Surg Res, 2011,171(2):675-683. DOI: 10.1016/j.jss.2010.03.053. doi: 10.1016/j.jss.2010.03.053
[10]	Wang M, Meng B, Liu Y , et al. MiR-124 inhibits growth and enhances radiation-induced apoptosis in non-small cell lung cancer by inhibiting STAT3[J]. Cell Physiol Biochem, 2017,44(5):2017-2028. DOI: 10.1159/000485907. doi: 10.1159/000485907
[11]	Hu C, Zhuang W, Qiao Y , et al. Effects of combined inhibition of STAT3 and VEGFR2 pathways on the radiosensitivity of non-small-cell lung cancer cells[J]. Onco Targets Ther, 2019,12:933-944. DOI: 10.2147/OTT.S186559. doi: 10.2147/OTT
[12]	Klein C, Dokic I, Mairani A , et al. Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation[J]. Radiat Oncol, 2017,12(1):208. DOI: 10.1186/s13014-017-0939-0. doi: 10.1186/s13014-017-0939-0
[13]	Wang G, Xiao L, Wang F , et al. Hypoxia inducible factor-1α/B-cell lymphoma 2 signaling impacts radiosensitivity of H1299 non-small cell lung cancer cells in a normoxic environment[J]. Radiat Environ Biophys, 2019,58(3):439-448. DOI: 10.1007/s00411-019-00802-4. doi: 10.1007/s00411-019-00802-4
[14]	Ikezawa Y, Sakakibara-Konishi J, Mizugaki H , et al. Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer[J]. Int J Clin Oncol, 2017,22(1):59-69. DOI: 10.1007/s10147-016-1031-8. doi: 10.1007/s10147-016-1031-8
[15]	Xu J, Patel NH, Saleh T , et al. Differential radiation sensitivity in p53 wild-type and p53-deficient tumor cells associated with senescence but not apoptosis or (nonprotective) autophagy[J]. Radiat Res, 2018,190(5):538-557. DOI: 10.1667/RR15099.1. doi: 10.1667/RR15099.1
[16]	Jung IL, Kang HJ, Kim KC , et al. PTEN/pAkt/p53 signaling pathway correlates with the radioresponse of non-small cell lung cancer[J]. Int J Mol Med, 2010,25(4):517-523. DOI: 10.3892/ijmm_00000372.
[17]	Chen QN, Wei CC, Wang ZX , et al. Long non-coding RNAs in anti-cancer drug resistance[J]. Oncotarget, 2017,8(1):1925-1936. DOI: 10.18632/oncotarget.12461. doi: 10.18632/oncotarget.v8i1
[18]	Yang YR, Zang SZ, Zhong CL , et al. Increased expression of the lncRNA PVT1 promotes tumorigenesis in non-small cell lung cancer[J]. Int J Clin Exp Pathol, 2014,7(10):6929-6935.
[19]	Liu AM, Zhu Y, Huang ZW , et al. Long noncoding RNA FAM201A involves in radioresistance of non-small-cell lung cancer by enhancing EGFR expression via miR-370[J]. Eur Rev Med Pharmacol Sci, 2019,23(13):5802-5814. DOI: 10.26355/eurrev_201907_18319.
[20]	Yang X, Zhang W, Cheng SQ , et al. High expression of lncRNA GACAT3 inhibits invasion and metastasis of non-small cell lung cancer to enhance the effect of radiotherapy[J]. Eur Rev Med Pharmacol Sci, 2018,22(5):1315-1322. DOI: 10.26355/eurrev_201803_14473.
[21]	Xue Y, Ni T, Jiang Y , et al. Long noncoding RNA GAS5 inhibits tumorigenesis and enhances radiosensitivity by suppressing miR-135b expression in non-small cell lung cancer[J]. Oncol Res, 2017,25(8):1305-1316. DOI: 10.3727/096504017-X14850182723737. doi: 10.3727/096504017X14850182723737
[22]	Jiang LP, He CY, Zhu ZT . Role of microRNA-21 in radiosensitivity in non-small cell lung cancer cells by targeting PDCD4 gene[J]. Oncotarget, 2017,8(14):23675-23689. DOI: 10.18632/oncotarget.15644. doi: 10.18632/oncotarget.v8i14
[23]	Chen X, Xu Y, Liao X , et al. Plasma miRNAs in predicting radiosensitivity in non-small cell lung cancer[J]. Tumour Biol, 2016,37(9):11927-11936. DOI: 10.1007/s13277-016-5052-8. doi: 10.1007/s13277-016-5052-8
[24]	Guo Y, Sun W, Gong T , et al. miR-30a radiosensitizes non-small cell lung cancer by targeting ATF1 that is involved in the phosphorylation of ATM[J]. Oncol Rep, 2017,37(4):1980-1988. DOI: 10.3892/or.2017.5448. doi: 10.3892/or.2017.5448
[25]	Shen Z, Wu X, Wang Z , et al. Effect of miR-18a overexpression on the radiosensitivity of non-small cell lung cancer[J]. Int J Clin Exp Pathol, 2015,8(1):643-648.
[26]	Liu G, Li YI, Gao X . Overexpression of microRNA-133b sensitizes non-small cell lung cancer cells to irradiation through the inhibition of glycolysis[J]. Oncol Lett, 2016,11(4):2903-2908. DOI: 10.3892/ol.2016.4316. doi: 10.3892/ol.2016.4316
[27]	Provencio M, Sánchez A, Garrido P , et al. New molecular targeted therapies integrated with radiation therapy in lung cancer[J]. Clin Lung Cancer, 2010,11(2):91-97. DOI: 10.3816/CLC.2010.n.012. doi: 10.3816/CLC.2010.n.012
[28]	Chinnaiyan P, Huang S, Vallabhaneni G , et al. Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva)[J]. Cancer Res, 2005,65(8):3328-3335. DOI: 10.1158/0008-5472.CAN-04-3547. doi: 10.1158/0008-5472.CAN-04-3547
[29]	Ma H, Bi J, Liu T , et al. Icotinib hydrochloride enhances the effect of radiotherapy by affecting DNA repair in colorectal cancer cells[J]. Oncol Rep, 2015,33(3):1161-1170. DOI: 10.3892/or.2014.3699. doi: 10.3892/or.2014.3699
[30]	Xie B, Sun L, Cheng Y , et al. Epidermal growth factor receptor gene mutations in non-small-cell lung cancer cells are associated with increased radiosensitivity in vitro[J]. Cancer Manag Res, 2018,10:3551-3560. DOI: 10.2147/CMAR.S165831. doi: 10.2147/CMAR

非小细胞肺癌放射敏感性标志物

Radiosensitivity markers of non-small cell lung cancer

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