国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (6): 362-364.doi: 10.3760/cma.j.issn.1673-422X.2018.06.010

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微小RNA-495在神经胶质瘤中的作用机制

张园园，朱淑霞   

  1. 256600 滨州医学院附属医院儿童血液与神经病区
  • 收稿日期:2018-03-14 出版日期:2018-06-08 发布日期:2018-07-31
  • 通讯作者: 朱淑霞 E-mail:zhusx2003@163.com

Mechanism of microRNA-495 in glioma

Zhang Yuanyuan, Zhu Shuxia   

  1. Department of Pediatric Blood and Neurology, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China
  • Received:2018-03-14 Online:2018-06-08 Published:2018-07-31
  • Contact: Zhu Shuxia E-mail:zhusx2003@163.com

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摘要： 微小RNA-495（miR-495）在许多肿瘤中特别是神经胶质瘤中表达异常，其通过调控细胞周期蛋白依赖性激酶6信号通路、葡萄糖转运体1型信号通路、MYB基因信号通路、独立生长因子1信号通路、高迁移率族核小体结合域5信号通路参与肿瘤细胞的增殖、凋亡、周期调控、新陈代谢及侵袭转移。对miR-495进行深入研究可能为阐明神经胶质瘤的发病机制及其诊疗提供新方向。

关键词: 微RNAs, 神经胶质瘤, 信号传导

Abstract: MicroRNA-495 (miR-495) is abnormally expressed in many tumors, especially in glioma. It involves in the proliferation, apoptosis, cycle regulation, metabolism, invasion and metastasis of tumor cells by regulating cyclin dependent kinase 6 signaling pathway, glucose transporter type 1 signaling pathway, MYB signaling pathway, growth factor independent 1 signaling pathway and high mobility group nucleosome binding domain 5 signaling pathway. Further study of miRNA-495 might provide a novel direction for clarifying the pathogenesis, diagnosis and treatment of glioma.

Key words: MicroRNAs, Glioma, Signal transduction