国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 693-.doi: 10.3760/cma.j.issn.1673422X.2015.09.014

• 综述 • 上一篇    下一篇

循环微小RNA在肺癌中的研究进展

曲莉莉, 刘晓晴   

  1. 军事医学科学院附属医院肺部肿瘤内科
  • 出版日期:2015-09-08 发布日期:2015-08-12

Circulating microRNA in lung cancer

QU  Li-Li, LIU  Xiao-Qing   

  1. Department of Lung Cancer, Affiliated Hospital of Academy of Military Medical Science
  • Online:2015-09-08 Published:2015-08-12

摘要: 微小RNA(miRNA)主要在转录后水平通过mRNA降解和抑制蛋白质翻译的方式负调控靶基因,其表达失控可直接或间接促进肿瘤的发生或发展。有研究显示,循环miRNA具有较好的稳定性,其有望作为新的肿瘤标志物应用于恶性肿瘤的诊疗。

Abstract: MicroRNAs (miRNAs) negatively mediate the post transcriptional target genes by degrading mRNAs and inhibiting translation of protein. Deregulation of miRNAs are directly or indirectly correlated with tumorigenesis and development of cancer. Currently, the application of miRNAs as a noninvasive potential biomarker with high stability is under investigation.