国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 576-579.doi: 10.3760/cma.j.issn.1673422X.2015.08.005

• 论著 • 上一篇    下一篇

胃腺癌组织中基质金属蛋白酶13和p73的表达及意义

王瑞才, 朱建友, 张海鹏, 徐少艳, 王爱云   

  1. 255400 山东省淄博市临淄区人民医院病理科
  • 出版日期:2015-08-08 发布日期:2015-06-29
  • 通讯作者: 王瑞才，Email：da_lian@qq.com E-mail:da_lian@qq.com

Expressions and clinical signifcances of matrix metalloproteinase13 and p73 in gastric adenocarcinoma

 WANG  Rui-Cai, ZHU  Jian-You, ZHANG  Hai-Peng, XU  Shao-Yan, WANG  Ai-Yun   

  1. Department of Pathology, Linzi People′s Hospital of Zibo City, Shandong Province, Zibo 255400, China
  • Online:2015-08-08 Published:2015-06-29
  • Contact: Wang Ruicai E-mail:da_lian@qq.com

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摘要： 目的研究MMP13、抑癌基因p73在胃腺癌组织中的表达及其与临床病理参数的关系，评估其对胃腺癌转移预后的意义。方法应用免疫组织化学SP法检测MMP13、抑癌基因p73在143例胃腺癌组织、55例癌旁正常组织中的表达情况，并分析其与临床病理参数的关系。结果胃腺癌组织中MMP13的表达显著高于癌旁组织（67.13%∶16.35%），差异有统计学意义（χ2=41.10，P=0.000）；p73的表达也显著高于癌旁组织（58.74%∶12.73%），差异有统计学意义（χ2=33.86，P=0.000）。胃腺癌中MMP13阳性表达与胃周围淋巴结转移（χ2=11.835，P=0.001）、浸润深度（χ2=5.177，P=0.032）、临床分期（χ2=11.107，P=0.001）有关，而与患者年龄（χ2=0.113，P=0.853）、肿瘤大小（χ2=0.338，P=0.591）、癌细胞分化程度（χ2=3.628，P=0.072）无关。胃腺癌中p73阳性表达与胃周围淋巴结转移（χ2=11.440，P=0.001）、癌细胞分化程度（χ2=5.407，P=0.025）及临床分期有关（χ2=9.497，P=0.003），而与患者年龄（χ2=1.567，P=0.222）、肿瘤大小（χ2=0.841，P=0.392）及浸润深度（χ2=0.554，P=0.498）无关，二者在胃腺癌组织中的表达呈正相关（r=0.684，P=0.000）。结论MMP13和p73可能共同参与胃腺癌的发生发展过程，可作为评估胃腺癌浸润和转移的重要生物学指标。

关键词: 胃肿瘤, 腺癌, 免疫组织化学, 基质金属蛋白酶13, p73

Abstract: ObjectiveTo study the expressions of matrix metalloproteinase13 (MMP13) and p73 in gastric adenocarcinoma, and to explore the associations of the expressions of MMP13 and p73 with the clinicopathological features, and to evaluate their clinical significances for the prognosis of gastric adenocarcinoma metastasis. MethodsThe immunohistochemistry SP methods was used to evaluate the expressions of MMP13 and p73 in 143 cases of gastric adenocarcinoma and 55 normal tissues adjacent to carcinoma, and their associations to the clinicopathologic features were analyzed. ResultsThe expression of MMP13 in gastric adenocarcinoma was significantly higher than that in adjacent tissues of cancer (67.13% vs 16.35%), with a significant difference (χ2=41.10, P=0.000). The expression of p73 in gastric adenocarcinoma was significantly higher than that in adjacent tissues of cancer (58.74% vs 12.73%), with a significant difference (χ2=33.86, P=0.000). In the gastric adenocarcinoma, the expression of MMP13 was associated with peripheral lymph node metastasis (χ2=11.835, P=0.001), depth of invasion (χ2=5.177, P=0.032) and TNM stage (χ2=11.107, P=0.001), but it was not correlated with the ages of patients (χ2=0.113, P=0.853), tumor size (χ2=0.338, P=0.591) and tumor differentiation level (χ2=3.628, P=0.072). In the gastric adenocarcinoma, the expression of p73 was associated with peripheral lymph node metastasis (χ2=11.440, P=0.001), tumor differentiation level (χ2=5.407, P=0.025) and TNM stage (χ2=9.497, P=0.003), but it was not correlated with the ages of patients (χ2=1.567, P=0.222), tumor size (χ2=0.841, P=0.392) and depth of invasion (χ2=0.554, P=0.498). The expression of MMP13 was positively correlated with the expression of p73 in gastric adenocarcinoma group (r=0.684, P=0.000). ConclusionBoth MMP13 and p73 may participate in the development of gastric adenocarcinoma, which can be used as an important index for the evaluation of invasiveness and metastasis in gastric adenocarcinoma.

Key words: Stomach neoplasms, Adenocarcinoma, Immunohistochemistry, Matrix metalloproteinase 13, p73