经典Wnt信号通路对卵巢癌发生发展的影响

doi:10.3760/cma.j.issn.1673-422X.2014.11.014

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (11): 844-847.doi: 10.3760/cma.j.issn.1673-422X.2014.11.014

经典Wnt信号通路对卵巢癌发生发展的影响

050011 石家庄,河北医科大学第四医院妇产科（刘翠莲、王利飞、郝淑维）；白求恩医务士官学校医学技术系（崔澂）

出版日期:2014-12-03 发布日期:2015-01-20
通讯作者: 郝淑维，Email: haoshuwei@sina.com

Influence of canonical Wnt signaling pathway on the occurrence and development of ovarian cancer

Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

Online:2014-12-03 Published:2015-01-20
Contact: Hao Shuwei, Email: haoshuwei@sina.com

摘要/Abstract

摘要： 经典 Wnt信号通路是近几年来卵巢癌发生相关信号通路研究的热点，激活后可诱导卵巢癌干细胞增殖及自我更新、存活及转移，其主要成员靶基因突变及传导通路负性调控分子异常表达与卵巢癌发生发展密切相关。深入了解经典Wnt信号通路在卵巢癌中的调控机制，并以此为抗卵巢癌治疗靶点进行基础研究及临床前期实验，可为临床更好地治疗卵巢癌提供理论依据。

关键词: 卵巢肿瘤； &beta, 连环素；钙黏着糖蛋白类；信号传导

Abstract: The canonical Wnt signaling pathway has been the hot spot in the signaling pathway studies which are related to ovary carcinogenesis in recent years, whose activation may induce the multiplication and selfrenewal, survival and metastasis of ovarian cancer stem cells. The target gene mutations of key members in the canonical Wnt pathway and abnormal expresses of negative regulation molecules are closely associated with the occurrence and development of ovarian cancer. Deeply investigating the regulative mechanisms of canonical Wnt signaling pathway in ovarian cancer, and taking this as the therapeutic target to conduct the basic research and preclinical experiment may provide theoretical basis for treating better ovarian cancer patients in clinical practice.

Key words: Ovarian neoplasms, Beta catenin, Cadherins, Signal transduction

刘翠莲, 崔澂, 王利飞, 郝淑维. 经典Wnt信号通路对卵巢癌发生发展的影响[J]. 国际肿瘤学杂志, 2014, 41(11): 844-847.

LIU Cui-Lian, CUI Cheng, WANG Li-Fei, HAO Shu-Wei. Influence of canonical Wnt signaling pathway on the occurrence and development of ovarian cancer[J]. Journal of International Oncology, 2014, 41(11): 844-847.

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经典Wnt信号通路对卵巢癌发生发展的影响

Influence of canonical Wnt signaling pathway on the occurrence and development of ovarian cancer

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