国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (10): 731-733.doi: 10.3760/cma.j.issn.1673-422X.2014.10.004

• 综述 • 上一篇    下一篇

Polι与肿瘤

孙昊尧, 周俊东, 孟星君, 李晓庆, 虞健, 吴锦昌   

  1. 215001南京医科大学附属苏州医院放疗科

  • 出版日期:2014-10-29 发布日期:2014-10-11
  • 通讯作者: 吴锦昌，E-mail: wjinchang@sina.com E-mail:wjinchang@sina.com
  • 基金资助:

    国家自然科学基金（８１３７２４３３）；江苏省自然科学基金
    （ＢＫ２０１３１１４９）

DNA polymerase iota and cancer

SUN  Hao-Yao, ZHOU  Jun-Dong, MENG  Xing-Jun, LI  Xiao-Qing, YU  Jian, WU  Jin-Chang   

  1. Department of Radiation Oncology, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, China 

  • Online:2014-10-29 Published:2014-10-11
  • Contact: Wu Jinchang E-mail:wjinchang@sina.com

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摘要： DNA聚合酶iota（Polι）与DNA修复基因Rev1、DNA聚合酶kappa（Polκ）、DNA聚合酶eta（Polη）同为Y家族聚合酶，能通过跨损伤修复对损伤DNA进行修复。但是在所有的DNA聚合酶中，Polι具有最低的保真性，在错误和正确模板的情况下都有很高的错配几率，且能够跨过一些DNA损伤将错配累积起来。最近研究表明Polι在一些肿瘤组织中表达异常，包括人葡萄膜黑色素瘤、乳腺癌、膀胱癌、肺癌和食管癌。异常表达的Polι与肿瘤发生发展关系密切，其修复DNA损伤的功能可能与肿瘤的放化疗抵抗相关。

关键词:

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Abstract: DNA polymerase iota (Polι), as well as Rev1, Polκ and Polη, are all Y family DNA polymerases, which are able to replicate damaged DNA via translesion synthesis pathway. However, Polι has the lowest fidelity among all DNA polymerases in both correct and inaccurate DNA templates. Also Polι can bypass certain DNA damages and accumulate mutations. Recent studies show that the aberrant expression of Polι is observed in human uveal melanoma, breast cancer, bladder cancer, lung cancer and esophageal cancer, which may contribute to the tumorigenesis and progression of tumor. The special role of Polι in replicating damaged DNA may contribute to the resistance in oncotherapy.

Key words: DNA damage, DNA repair enzymes, Esophageal neoplasms