国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (8): 612-614.

• 综述 • 上一篇    下一篇

一氧化氮∕一氧化氮合酶信号系统与前列腺癌

李爱玲, 修瑞娟   

  1. 100005 北京，中国医学科学院微循环研究所
  • 出版日期:2013-08-08 发布日期:2013-08-15

NO/NOS system in prostate cancer

LI  Ai-Ling, XIU  Rui-Juan   

  1. Institute of Microcirculation, Chinese Academy Medical Sciences (CAMS), Beijing 100005,China
  • Online:2013-08-08 Published:2013-08-15

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摘要： 一氧化氮（NO）作为体内重要的信使分子，其生物学作用复杂、多样, 与一氧化氮合酶（NOS）活性及表达密切相关。NO通过G蛋白受体激活的信号转导途径参与肿瘤细胞增殖、迁移和血管新生，与前列腺癌的发生、发展密切相关。NO供体药物及NOS抑制剂具有抗肿瘤和放化疗增敏的作用。

关键词: 一氧化氮, 一氧化氮合酶, 前列腺肿瘤, 血管生成调节剂

Abstract: Via activating G-protein receptor transduction pathways, nitric oxide(NO)，an important signal molecule, has a complex and diverse role which is closely related with activity and gene expression of nitric oxide synthetase (NOS). NO is involved in tumor related events such as cellular proliferation, migration，especially the angiogenic process, and it is closely related with the occurrence and progression of prostate cancer. NO donors and NOS inhibitors have anti-cancer and radio-chemotherapy enhancement roles.

Key words: Nitric oxide, Nitric oxide synthase, Prostatic neoplasmas, Angiogenesis modulating agents