国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (7): 549-551.

• 论著 • 上一篇    下一篇

斑蝥酸钠维生素B6注射液改善局部晚期鼻咽癌放化疗期间癌症相关性乏力的疗效观察

王萍, 陶磊, 王大荣, 杨志勇, 刘静, 姬生威   

  1. 438000湖北省黄冈市中心医院肿瘤科（王萍、王大荣、刘静、姬生威），放疗中心(杨志勇)，湖北省黄冈市妇女儿童医院（陶磊）
  • 出版日期:2013-07-08 发布日期:2013-07-08

Curative effect observation of disodium cantharidinate and vitamin B6 injection to improve the cancer-related fatigue in nasopharyngeal carcinoma patients of Ⅲ-ⅣB stage undergoing radiotherapy and chemotherapy 

WANG  Ping, TAO  Lei, WANG  Da-Rong, YANG  Zhi-Yong, LIU  Jing, JI  Sheng-Wei   

  1. Department of Oncology, Huanggang Central Hospital, Huanggang 438000, China
  • Online:2013-07-08 Published:2013-07-08

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摘要：  目的 探讨斑蝥酸钠维生素B6注射液在治疗局部晚期鼻咽癌患者放化疗期间癌症相关性乏力(CRF)中的作用。  方法 2011年12月至2012年5月我院收治的合并有乏力症状的80例Ⅲ～ⅣB期鼻咽癌患者，均采取同步放化疗后序贯3周期以铂类为主的化疗。分为两组，一组40例在治疗同时静脉滴注斑蝥酸钠维生素B6注射液（治疗组），另一组40例仅常规治疗（对照组）；依据简明乏力评估量表（BFI）于治疗前（基线值）、治疗第8周、第20周做乏力问卷评分，比较两组患者乏力程度的变化及Ⅲ～Ⅳ度不良反应的发生情况。  结果 治疗第8周时，两组CRF无明显差异（?2=1.758，P =0.32）,治疗第20周时，治疗组较对照组能明显改善患者CRF；治疗组Ⅲ～Ⅳ度不良反应发生率也明显低于对照组（?2=8.12，P=0.005）。  结论 斑蝥酸钠维生素B6注射液可以改善Ⅲ～ⅣB期鼻咽癌患者放化疗期间的CRF程度，并能有效降低Ⅲ～Ⅳ度骨髓抑制、口腔黏膜炎及胃肠道反应的发生率（?2=6.144，P=0.031）。

关键词:  鼻咽肿瘤, 疲劳, 斑蝥酸钠维生素B6注射液

Abstract: Objective  To investigate the effectiveness of disodium cantharidinate and vitamin B6 injection for cancer-related fatigue in nasopharyngeal carcinoma patients of Ⅲ-ⅣB stage undergoing radiotherapy and chemotherapy. Methods  Eighty nasopharyngeal carcinoma patients of Ⅲ-ⅣB stage with fatigue symptoms from December 2011 to May 2012 in our hospital were divided into two groups. All patients received treatment of sequential 3 cycles with platinum-based chemotherapy after concurrent chemoradiation. One group of 40 patients also received intravenous infusion of disodium cantharidinate and vitamin B6 injection (experimental group), the other group of 40 patients only received conventional therapy (control group). Brief fatigue inventory (BFI) questionnaires data were collected at baseline, the eighth week and the twentieth week after treatment. The changes of fatigue severity and the occurrence of Ⅲ~Ⅳ degree adverse reactions in the two groups were compared . Results  At the eighth week, the improvement in fatigue severity was not significantly different between two groups (?2=1.758, P=0.32). However, significant improvement in cancer-related fatigue of experimental group was found than that of control group at the twentieth week. The Ⅲ~Ⅳ degree adverse reactions of experimental group were significantly lower than that of control group (?2=8.12, P=0.005). Conclusion  Disodium cantharidinate and vitamin B6 injection combined with radiotherapy and chemotherapy can improve the cancer-related fatigue of nasopharyngeal carcinoma patients of Ⅲ~ⅣB stage and it can also reduce the incidence rate of Ⅲ~Ⅳ degree adverse reactions (?2=6.144, P=0.031).

Key words: Nasopharyngeal neoplasms, Fatigue, Disodium cantharidinate and vitamin B6 injection