国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (7): 486-488.

• 综述 • 上一篇    下一篇

线粒体在肿瘤发生中的作用

张百红, 岳红云   

  1. 730050 兰州军区兰州总医院肿瘤科(张百红),眼科(岳红云)
  • 出版日期:2013-07-08 发布日期:2013-07-08
  • 通讯作者: 张百红,bhzhang1999@126.com E-mail:bhzhang1999@126.com
  • 基金资助:

    兰州军区“十二五”医学科技专项课题(2012-06)

Roles of the mitochondria in tumorigenesis 

ZHANG  Bai-Hong, YUE  Hong-Yun   

  1. Roles of the mitochondria in tumorigenesis
  • Online:2013-07-08 Published:2013-07-08
  • Contact: ZHANG Bai-Hong E-mail:bhzhang1999@126.com

摘要: Ι线粒体作为半自主的细胞器,容易受到外界因子的损伤。线粒体功能改变,如氧化磷酸化损伤、能量代谢异常、抑制凋亡、自噬障碍、促进免疫逃避和信号通路改变,可能影响肿瘤的发生。调变线粒体功能可能预防肿瘤的发生。

关键词: 线粒体&Iota, 肿瘤&Iota, 肿瘤发生

Abstract: As semi-autonomous organelles, mitochondria are easily damaged by various factors. Mitochondrial dysfunction such as abnormal oxidative phosphorylation, metabolism alterations, apoptosis prevention, damaged mitophagy, immune escape and deregulated signaling pathway have been hypothesized to be involved in tumorigenesis. Modulated mitochondria may prevent the occurrence of tumors.

Key words: Mitochondria&Iota, Neoplasms&Iota, Tumorigenesis