国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (6): 406-409.

• 综述 • 上一篇    下一篇

癌基因Pim-1在肿瘤中的研究

徐加杰, 王可敬, 葛明华   

  1. 310022 杭州，浙江省肿瘤医院头颈外科
  • 出版日期:2013-06-08 发布日期:2013-05-24
  • 通讯作者: 葛明华，E-mail：gemingh@163.com E-mail:gemingh@163.com
  • 基金资助:

    国家自然科学基金（81202127）  浙江省医药卫生科技计划项目（2010KYA033、2012KYA031）

Oncogene Pim-1 and Tumor

XU  Jia-Jie, WANG  Ke-Jing, GE  Ming-Hua   

  1. Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China
  • Online:2013-06-08 Published:2013-05-24
  • Contact: GE Ming-hua E-mail:gemingh@163.com

PDF

1560

被引次数

1

摘要： 癌基因Pim-1与多种肿瘤的发生发展密切相关，参与多个信号转导通路，调节下游生物因子的表达，或与其他癌基因协同作用，在相关肿瘤的诊断、治疗及预后评估中具有重要作用，同时也提供了新的潜在靶点。目前以Pim-1为靶点，探索治疗肿瘤的新策略成为研究热点，将有望用于肿瘤临床治疗。

关键词:

text-indent: 24pt, margin: 0cm 0cm 0pt, mso-char-indent-count: 2.0" class="MsoNormal">font-family: 宋体, font-size: 12pt, mso-ascii-font-family: 'Times New Roman', mso-hansi-font-family: 'Times New Roman'">原癌基因, font-family: 宋体, font-size: 12pt, mso-ascii-font-family: 'Times New Roman', mso-hansi-font-family: 'Times New Roman'">丝氨酸苏氨酸蛋白质激酶, font-family: 宋体, font-size: 12pt, mso-ascii-font-family: 'Times New Roman', mso-hansi-font-family: 'Times New Roman'">细胞凋亡font-size: 12pt" lang="EN-US">

Abstract: Oncogene Pim-1 has a close relationship with the occurrence and development of several tumours. It is involved in a number of signal transduction pathways and regulates the expression of the downstream biological factors or acts synergistically with other oncogenes. Pim-1 plays an important role in the clinical diagnosis, treatment and prognosis of some tumors, and provides a new potential target in the chemotherapy of tumors. Recently, Pim-1-targeting treatment strategy has be a research hotspot and it would be used for cancer clinical treatment hopefully.

Key words: Oncogene, Serine threonine protein kinase, Apoptosis