国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (2): 120-122.

• 综述 • 上一篇    下一篇

肺腺癌发展模式

杨振宇, 樊志文, 张雷   

  1. 410013 长沙，中南大学湘雅医学院临床医学专业
  • 出版日期:2013-02-08 发布日期:2013-01-25
  • 通讯作者: 张雷，E-mail：chinaray728@gmail.com E-mail:chinaray728@gmail.com

Lung adenocarcinoma progression schema

YANG  Zhen-Yu, FAN  Zhi-Wen, ZHANG  Lei   

  1. Clinical Medical Specialty , Xiangya School of Medicine, Central South University, Changsha 410013, China
  • Online:2013-02-08 Published:2013-01-25
  • Contact: Corresponding author: ZHANG Lei, E-mail: chinaray728@gmail.com E-mail:chinaray728@gmail.com

PDF

1881

摘要： 目前普遍认为肺腺癌遵循直线式多阶段的发展模式，即癌前病变发展为原位腺癌，再进展为微浸润性腺癌，最后有些肺腺癌发生扩散。然而近期研究揭示，并非所有的肺腺癌亚型都遵循直线式的发展模式，某些亚型符合一种非直线式的发展模式。对这两种发展模式进行探讨有助于肺腺癌的早期诊断。

关键词: 肺肿瘤, DNA甲基化, 病因学

Abstract: Lung adenocarcinoma is usually thought to follow a linear multistep progression schema, that is precancerous lesions progress to adenocarcinoma in situ, and progress to micro-invasive adenocarcinoma, eventually some lung adenocarcinoma happen diffusion. However, recent ?ndings reveal that this linear progression schema might not occur in all lung adenocarcinoma subtypes, and some subtypes show a kind of non-linear progression schema. The study of these two kinds of schemas can help for early detection of lung adenocarcinoma.

Key words: Lung neoplasms, DNA methylation, Etiology