国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (1): 47-50.

• 综述 • 上一篇    下一篇

非小细胞肺癌疗效预测因子基因多态性的研究

刘晓琳, 宋晓明   

  1. 250014 山东省千佛山医院 山东大学附属千佛山医院肿瘤科（刘晓琳），胸外科（宋晓明）
  • 出版日期:2013-01-08 发布日期:2013-01-15
  • 基金资助:

    山东省自然科学基金（2005ZX04）

Gene polymorphisms of prognostic factors in non-small cell lung cancer

LIU  Xiao-Lin, SONG  Xiao-Ming   

  1. Department of Oncology, Qianfoshan Hospital, Affiliated Hospital of Shandong University, Jinan 250014, China
  • Online:2013-01-08 Published:2013-01-15

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摘要：     切除交错互补修复基因、核糖核苷酸还原酶M1亚单位、P53、表皮生长因子受体、血管表皮生长因子与非小细胞肺癌（NSCLC）的疗效及预后密切相关。近年来，许多研究对上述因子的多态性与NSCLC疗效及预后进行相关探讨，其基因多态性有望成为NSCLC患者的预后预测标志。

关键词: 癌, 非小细胞肺, 预后, 多态现象, 遗传

Abstract:      Many studies show that excision repair cross-complementing gene 1 (ERCC1), ribonucleotide reductase subunit M1 (RRM1), P53, epidermal growth factor receptor (EGFR), and vascular endothelial growth factor (VEGF) are closely related to the curative effect and prognosis of non-small cell lung cancer (NSCLC). In recent years, many studies have investigated the association between polymorphisms of these factors and the curative effect and prognosis in patients with NSCLC. The polymorphisms of these factors may be potential biomarkers to predict the clinical outcome in patients with NSCLC.

Key words: Carcinoma, non-small cell lung, Prognosis, Polymorphism, genetic