国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (7): 489-492.
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乔恩奇, 唐金海, 吴建中
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国家自然科学基金资助项目（30840093）
QIAO En-qi, TANG Jin-Hai, WU Jian-Zhong
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摘要： P-糖蛋白（P-gp）及其编码基因mdr1的过表达是肿瘤多药耐药（MDR）的经典机制。研究发现，孕烷X受体(PXR)可介导P-gp的表达，已证实PXR还具有抑制肿瘤细胞凋亡作用。因此，特异性地阻断PXR的活化可能是阻止MDR的新方法。
关键词: 抗药性, 肿瘤, P糖蛋白, 孕烷X受体
Abstract: The overexpression of P-glycoprotein (P-gp) and its coding gene mdr1 is regarded as the classic mechanism of multidrug resistance (MDR). Recent studies find that pregnane X receptor (PXR) can mediate the expression of P-gp. It is confirmed that PXR can also inhibit apoptosis of tumor cells. Therefore, preventing the activation of PXR specifically may be a new method to prevent MDR.
Key words: Drug resistance, neoplasm, P-glycoprotein, Pregnane X receptor
乔恩奇, 唐金海, 吴建中. 孕烷X受体与肿瘤多药耐药的相关性[J]. 国际肿瘤学杂志, 2012, 39(7): 489-492.
QIAO En-qi, TANG Jin-Hai, WU Jian-Zhong. Pregnane X receptor and tumor multidrug resistance[J]. Journal of International Oncology, 2012, 39(7): 489-492.
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