国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (3): 218-220.

• 综述 • 上一篇    下一篇

表皮生长因子受体在食管癌放疗中的应用

张和平, 李建成   

  1. 350014  福建医科大学附属教学医院福建省肿瘤医院放疗科16病区
  • 出版日期:2012-03-08 发布日期:2012-02-24
  • 通讯作者: 李建成，Email: jianchengLi6@126.com E-mail:jianchengLi6@126.com
  • 基金资助:

    福建省卫生创新课题(2007-CX-4)

Application of epidermal growth factor receptor for radiotherapy of esophageal cancer

ZHANG  He-Ping, LI  Jian-Cheng   

  1. Department of Radiation Oncology, Affiliated Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China
  • Online:2012-03-08 Published:2012-02-24
  • Contact: LI Jian-cheng, E-mail: jianchengLi6@126.com E-mail:jianchengLi6@126.com

PDF

1606

被引次数

8

摘要： 表皮生长因子受体（EGFR）在食管癌中高表达或突变，引起肿瘤对放疗的抗拒，导致放疗效果差。抗EGFR治疗具有肿瘤放疗增敏作用，目前针对EGFR的分子靶向研究主要有人工合成的单克隆抗体、小分子酪氨酸激酶抑制剂、RNA干扰（RNAi）下调受体表达。

关键词: color: black, font-family: 宋体, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-bidi-font-family: 'Times New Roman', mso-font-kerning: 1.0pt, mso-hansi-font-family: 'Times New Roman', mso-ascii-font-family: 'Times New Roman'">食管肿瘤, 受体,表皮生长因子, color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt">RNAcolor: black, font-family: 宋体, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-bidi-font-family: 'Times New Roman', mso-font-kerning: 1.0pt, mso-hansi-font-family: 'Times New Roman', mso-ascii-font-family: 'Times New Roman'">干扰

Abstract: Epidermal growth factor receptor (EGFR) express highly or mutant in esophageal cancer, which causing tumor resistance to radiotherapy and leading to poor radiotherapeutic effects. Treatment with anti-EGFR can get radiosensitization. There are three main types of molecular targeted research for EGFR: synthetic monoclonal antibody, small molecule tyrosine kinase inhibitors, and other strategies modulating EGFR biosynthesis based on RNA interference.

Key words:

line-height: 150%">color: black, line-height: 150%">Esophageal neoplasms, line-height: 150%, mso-bidi-font-size: 7.5pt">Receptor, epidermal growth factor, color: black, line-height: 150%">RNA interference