国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (3): 176-179.

• 综述 • 上一篇    下一篇

securin的功能及在肿瘤中的研究进展

郭宏艳, 金惠琴, 张云霏, 张煦   

  1. 730000 兰州，甘肃省第二人民医院病理科（郭宏艳、金惠琴、张云霏）；兰州大学基础医学院病理研究所（张煦）
  • 出版日期:2012-03-08 发布日期:2012-02-24
  • 基金资助:

    甘肃省科技计划资助项目（1107RJZA205）

Function of securin and its research advances in tumor

GUO  Hong-Yan, JIN  Hui-Qin, ZHANG  Yun-Fei, ZHANG  Xu   

  1. Department of Pathology, Second People’s Hospital of Gansu, Lanzhou 730000, China
  • Online:2012-03-08 Published:2012-02-24

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摘要： securin是垂体肿瘤转化基因编码的具有多种功能的蛋白，在有丝分裂中期向后期的过渡中负责调控姐妹染色单体的分离。Securin表达异常在多种内分泌腺体及腺体相关癌症被发现，如脑垂体瘤、甲状腺癌、卵巢癌、结肠癌等。securin在这些癌症中的作用机制与其顺时转化作用及与其他癌症相关蛋白如p21、p53等有关。

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Abstract: Securin is a multifunctional protein which is encoded by pituitary tumor-transforming gene. In the metaphase to anaphase transition during mitosis, securin is involved in sister chromatid separation. The aberrant expression of securin is found in many endocrine glands and related cancers, such as pituitary tomour, thyroid cancer, ovarian cancer, colon cancer and so on. The function of securin in cancer is related to its gene transactivation and association with other poteins like p21, p53.

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