国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (12): 895-898.

• 综述 • 上一篇    下一篇

组蛋白脱乙酰基酶7与肿瘤新生血管生成

徐兴东, 杨波   

  1. 213003 常州，苏州大学附属第三医院肝胆外科

  • 出版日期:2012-12-08 发布日期:2012-11-15
  • 通讯作者: 杨波，E-mail: yangboo72@yahoo.com.cn E-mail:yangbo72@yahoo.com.cn

Histone deacetylase 7 and tumor angiogenesis

XU  Xing-Dong, YANG  Bo   

  1. Department of Hepatobiliary Surgery，The Third Affiliated Hospital，Soochow University， Changzhou 213003, China
  • Online:2012-12-08 Published:2012-11-15
  • Contact: Corresponding author: YANG Bo, E-mail: yangbo72@yahoo.com.cn E-mail:yangbo72@yahoo.com.cn

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摘要： 组蛋白脱乙酰基酶7（HDAC7）属于Ⅱa型组蛋白脱乙酰基酶，其能够改变染色质结构以及调控基因转录，同时在肿瘤发生和肿瘤新生血管生成等一系列病理生理过程中发挥重要作用。研究发现，HDAC7能够维持血管的完整性和连续性，调控血管生成相关基因的表达，同时能够调控血管内皮细胞的增殖和迁移、调节血管内皮生长因子（VEGF）介导的血管生成效应以及调节其他促血管生成因子对血管的作用。因此，探讨HDAC7参与肿瘤新生血管生成的机制以及HDAC7抑制剂的研发将为肿瘤诊断和治疗提供新的方向。

关键词: 组蛋白脱乙酰激酶类, 血管内皮生长因子类, 新生血管化, 病理性

Abstract: Histone deacetylase7(HDAC7) belongs to Ⅱa histone deacetylases. HDAC7 can alter chromosome structure and regulate gene transcription, and plays an important role in tumorigenesis and tumor angiogenesis. Increasing evidences show that HDAC7 can maintain the vascular integrity and continuity, and regulate the expression of angiogenic genes. HDAC7 also can regulate the migration and proliferation of vascular endothelial cells, and regulate angiogenic effect mediated by VEGF and other proangiogenenic factors contributing to tumor angiogenesis. Therefore, studies of the mechanisms in which HDAC7 contributes to tumor angiogenesis and the development of HDAC7 inhibitors could provide a new direction to tumor diagnosis and therapy.

Key words: Histone deacetylases, Vascular endothelial growth factors, Neovascularization, pathologic