Abstract: Allogeneic hematopoietic stem cell transplantation is the only measure which can cure multiple myeloma, but the high mortality rate related with it limited its use. Autologous hematopoietic stem cell transplantation（Auto-HSCT) has made a great contribution at improving the patients’ quality of life and prolonging the survival.In recent years, the application of new drugs and new chemotherapy regimen consisted of traditional chemotherapy and new drugs further enhance the curative effect.