国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (10): 783-786.

• 综述 • 上一篇    下一篇

黑色素瘤抗原A家族与肝细胞癌

张永俊, 张文敏   

  1. 350004 福州，福建医科大学基础医学院病理学系 福建医科大学肿瘤研究室
  • 出版日期:2011-10-08 发布日期:2011-09-27

Melanoma antigen A and hepatocellular carcinoma

ZHANG  Yong-Jun, ZHANG  Wen-Min   

  1. Departmengt of Pathology, Cancer Institute, Fujian Medical University, Fuzhou 350004, China
  • Online:2011-10-08 Published:2011-09-27

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摘要： 黑色素瘤抗原A(MAGE-A)是一组肿瘤相关性抗原，主要表达于以黑色素瘤为主的多种恶性肿瘤组织中。肝细胞癌(HCC)是发生于肝脏的上皮性恶性肿瘤，患病率高，寻找有效的诊断和治疗方法成为极其迫切的任务。目前已证实MAGE-A基因在HCC组织中高表达，对HCC诊治及预后判断具有重要意义。

Abstract: Melanoma antigen A is a kind of tumor-associated antigen, which expresses in various types of hunman malignant tumor tissues especially in melanoma. Hepatocellular carcinoma (HCC) is a kind of malignant epithelialtumor with high incidence which occurs in liver. Searching for effective diagnosis and treatment methods of it become a pressing task. It is confirmed that MAGE-A gene is highly expressed in HCC tissues which has great significance to the diagnosis, treatment and prognosis for HCC.