国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (10): 758-761.

• 综述 • 上一篇    下一篇

n-3多不饱和脂肪酸在乳腺癌综合治疗中的作用

张峰, 陈益定   

  1. 310016浙江大学医学院附属妇产科医院外科
  • 出版日期:2011-10-08 发布日期:2011-09-27
  • 通讯作者: 陈益定，E-mail: ydchen@zju.edu.cn E-mail:ydchen@zju.edu.cn

Role of n-3 polyunsaturated fatty acid in the combined treatment of breast cancer

ZHANG  Feng, CHEN  Yi-Ding   

  1. Department of Surgery, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
  • Online:2011-10-08 Published:2011-09-27

PDF

1854

被引次数

5

摘要： 乳腺癌是一种异质性肿瘤，代谢异常在乳腺癌的发生、发展中起重要作用。n-3多不饱和脂肪酸（PUFA）可以通过多种途径改变乳腺癌细胞的脂肪酸代谢，调节癌基因和抑癌基因的表达，从而在乳腺癌的化疗、放疗、内分泌治疗和分子靶向治疗等综合治疗中起作用。

Abstract: Breast cancer is a type of heterogenetic neoplasm. Metabolic dysfunction plays a pivotal role in the pathogenesis and progress of breast cancer. N-3 polyunsaturated fatty acid (PUFA) could change fatty acid metabolism of breast cancer cells and modulate expression of oncogenes and anti-oncogenes through various ways. It may provide therapeutic opportunities in the treatment of chemotherapy, radiotherapy, endocrine therapy and molecule targeted therapy of breast cancer.