国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (10): 738-741.

• 综述 • 上一篇    下一篇

sox4基因在肿瘤中的作用机制及异常表达

周永春, 王熙才, 黄云超   

  1. 650118 昆明医学院第三附属医院 云南省肿瘤研究所
  • 出版日期:2011-10-08 发布日期:2011-09-27
  • 通讯作者: 黄云超,E-mail: huangych2001@yahoo.com.cn E-mail:huangych2001@yahoo.com.cn

Mechanism and abnormal expression of the sox4 gene in tumor

ZHOU  Yong-Chun, WANG  Xi-Cai, HUANG  Yun-Chao   

  1. Yunnan Tumor Research Institute, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China
  • Online:2011-10-08 Published:2011-09-27

摘要: 近年的研究显示sox4基因在多种肿瘤组织中呈异常表达,与肿瘤的发生、发展及转移密切相关,其作用机制涉及对细胞的增殖、分化及凋亡等多方面的调控。深入研究该基因与肿瘤的关系,有望为研发肿瘤的特异性诊断标志和治疗靶点提供新的思路。

Abstract: Recent studies revealed that sox4geneexpresses abnormally in many kinds of tumor tissues and it probably involved in tumorigenesis, development and metastasis of cancer. Regulating proliferation, differentiation, apoptosis and other process may participate in the work mechanisms of sox4gene. Therefore, further studies about the relationship between sox4 gene and tumor would provide new ideas of exploring special diagnosis marker and novel target for tumor therapy.