国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (5): 380-382.doi: 10.3760/cma.j.issn.1673422X.2017.05.014

• 综述 • 上一篇    下一篇

表观遗传在抗血管生成治疗中的作用

王梅,蒋晓东   

  1. 222002 徐州医科大学附属连云港医院肿瘤科 肿瘤实验室
  • 出版日期:2017-05-08 发布日期:2017-04-19
  • 通讯作者: 蒋晓东,Email: jxdysy1970@163.com E-mail:jxdysy1970@163.com
  • 基金资助:

    江苏省自然科学基金(BK20151279)

The role of epigenetics on antiangiogenesis therapy

Wang Mei, Jiang Xiaodong   

  1.  Tumor Laboratory, Department of Oncology, Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222002, China
  • Online:2017-05-08 Published:2017-04-19
  • Contact: Jiang Xiaodong E-mail:jxdysy1970@163.com
  • Supported by:

    Natural Science Foundation of Jiangsu Province of China (BK20151279)

摘要: 表观遗传包括DNA甲基化、组蛋白翻译后修饰、微小RNA、长非编码RNA,其通过作用于不同靶点共同参与肿瘤的血管生成。表观遗传已成为肿瘤抗血管生成治疗的潜在靶点。

关键词: 血管生成抑制剂, 表观遗传

Abstract: Epigenetics consists of DNA methylation, posttranslational modification of histon, microRNA and long noncoding RNA, which regulate angiogenesis by acting on different targets. Epigenetics has become potential targets of antiangiogenesis in tumor.

Key words: Angiogenesis inhibitors, Epigenetics