国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (5): 392-394.doi: 10.3760/cma.j.issn.1673422X.2015.05.020

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 p70S6K1及4E-BP1蛋白在结直肠癌中的作用

  

  1. 济南军区总医院肿瘤科
  • 出版日期:2015-05-08 发布日期:2015-05-12
  • 通讯作者: 毕经旺 jingwangbi@live.cn

The effect of p70S6K1 and 4EBP1 protein in colorectal cancer

  1. Department of Oncology, The General Hospital of Jinan Military Command
  • Online:2015-05-08 Published:2015-05-12
  • Contact: Bi Jingwang jingwangbi@live.cn

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摘要： 磷脂酰肌醇激酶3-蛋白激酶B-雷帕霉素靶蛋白（mTOR) 信号通路在结直肠癌的发生、发展中发挥重要的作用。mTORC1下游靶点是核糖体S6蛋白激酶 1（p70S6K1）和真核翻译起始因子4E结合蛋白1（4EBP1），两者在蛋白质合成中起主要的调节作用。结直肠癌中p70S6K1及4EBP1的异常表达成为关注的焦点。

Abstract: The phosphatidylinositide3kinase (PI3K)/ protein kinase B (Akt)/ mammalian target of rapamycin (mTOR) pathway is recognized to have an important role in the development and progression of colorectal cancer (CRC). The most extensively characterized downstream targets of mTORC1 are ribosomal protein S6 kinase 1 (p70S6K1) and eukaryotic translation initiation factor (eIF) 4Ebinding protein 1 (4EBP1), both of which are crucial to the regulation of protein synthesis. The abnormal expression of p70S6K1 and 4EBP1 in CRC has become the focus of attention.

Key words: Colorectal neoplasms/Ribosomal protein S6 kinases, /Eukaryotic initiation factor4E