Merkel细胞多瘤病毒在Merkel细胞癌中的研究进展

doi:10.3760/cma.j.issn.1673-422X.2020.02.013

国际肿瘤学杂志 ›› 2020, Vol. 47 ›› Issue (2): 123-126.doi: 10.3760/cma.j.issn.1673-422X.2020.02.013

Merkel细胞多瘤病毒在Merkel细胞癌中的研究进展

乐张慧¹, 王焱²(), 方方², 孙建方¹

1 中国医学科学院北京协和医学院皮肤病研究所病理科,南京 210042
2 中国医学科学院北京协和医学院皮肤病研究所皮肤外科,南京 210042

收稿日期:2019-11-20 修回日期:2019-12-19 出版日期:2020-02-08 发布日期:2020-05-27
通讯作者: 王焱 E-mail:drwangyan@163.com
基金资助:
国家自然科学基金(81872216);中国医学科学院医学与健康科技创新工程(CIFMS-2017-I2M-1-017)

Advances of Merkel cell polyomavirus in the pathogenesis of Merkel cell carcinoma

Yue Zhanghui¹, Wang Yan²(), Fang Fang², Sun Jianfang¹

1 Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing 210042, China
2 Department of Dermatologic Surgery, Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing 210042, China

Received:2019-11-20 Revised:2019-12-19 Online:2020-02-08 Published:2020-05-27
Contact: Wang Yan E-mail:drwangyan@163.com
Supported by:
National Natural Science Foundation of China(81872216);Medical and Health Science and Technology Innovation Project of Chinese Acaderuy of Medical Science(CIFMS-2017-I2M-1-017)

摘要/Abstract

摘要：

Merkel细胞癌(MCC)是一种罕见但高侵袭性的皮肤肿瘤。近年来,关于MCC形态学、免疫表型和发病机制的研究取得了一些新的进展,其中Merkel细胞多瘤病毒(MCPyV)是MCC研究的一大突破。MCPyV(+)MCC患者在发病机制、临床特征及预后方面与未感染患者有明显区别。关于MCPyV的研究不仅揭示了MCC的部分发病机制,而且有助于探索其组织起源。此外,检测MCC患者血清中的MCPyV癌蛋白抗体可获得提示预后的信息,鉴定病毒状态和MCC肿瘤的突变谱可以更好地指导用药,有助于制定个体化临床治疗策略。

关键词: Merkel细胞癌, Merkel细胞多瘤病毒

Abstract:

Merkel cell carcinoma (MCC) is a rare, highly invasive skin tumor. In recent years, some new progress has been made in the research of MCC morphology, immunophenotype and pathogenesis. The discovery of Merkel cell polyomavirus (MCPyV) is a major breakthrough in MCC research. MCPyV-positive patients with MCC are significantly different from uninfected patients in pathogenesis, clinical characteristics and prognosis. Studies of MCPyV not only reveal some of the pathogenesis of MCC, but also contribute to exploring the tissue origin of MCC. In addition, detection of MCPyV oncoprotein antibodies in the serum can obtain prognostic information of patients with MCC. Identification of the virus status and the mutation profile of MCC tumors can better guide medication and help to develop individualized clinical treatment strategies.

Key words: Merkel cell carcinoma, Merkel cell polyomavirus

乐张慧, 王焱, 方方, 孙建方. Merkel细胞多瘤病毒在Merkel细胞癌中的研究进展[J]. 国际肿瘤学杂志, 2020, 47(2): 123-126.

Yue Zhanghui, Wang Yan, Fang Fang, Sun Jianfang. Advances of Merkel cell polyomavirus in the pathogenesis of Merkel cell carcinoma[J]. Journal of International Oncology, 2020, 47(2): 123-126.

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Merkel细胞多瘤病毒在Merkel细胞癌中的研究进展

Advances of Merkel cell polyomavirus in the pathogenesis of Merkel cell carcinoma

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