微小RNA在肺癌干细胞中的调控作用

doi:10.3760/cma.j.issn.1673-422X.2019.04.008

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (4): 231-234.doi: 10.3760/cma.j.issn.1673-422X.2019.04.008

微小RNA在肺癌干细胞中的调控作用

赵国丽^1，2,刘恒铫¹,张月英²

¹济南大学山东省医学科学院医学与生命科学学院 250200； ²山东省医学科学院基础医学研究所病理学与病理生理学研究室，济南 250062

收稿日期:2019-01-07 修回日期:2019-02-27 出版日期:2019-04-08 发布日期:2019-05-29
通讯作者: 张月英，Email: zhangyueying828@126.com E-mail:zhangyueying828@126.com
基金资助:
国家自然科学基金（81403150）；山东省自然科学基金（ZR2014HL064）；山东省中医药科技发展项目（2015-325）；山东省医学科学院医药卫生科技创新工程

Regulating effect of microRNAs in lung cancer stem cells

Zhao Guoli^1,2, Liu Hengyao¹, Zhang Yueying²

¹School of Medicine and Life Sciences, University of JinanShandong Academy of Medical Sciences, Jinan 250200, China; ²Laboratory of Pathology and Pathophysiology, Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences, Jinan 250062, China

Received:2019-01-07 Revised:2019-02-27 Online:2019-04-08 Published:2019-05-29
Contact: Zhang Yueying, Email: zhangyueying828@126.com E-mail:zhangyueying828@126.com
Supported by:
National Natural Science Foundation of China (81403150); Natural Science Foundation of Shandong Province of China (ZR2014HL064); Development Project of Traditional Chinese Medical Sciences and Technology of Shandong Province of China (2015-325); Innovation Project of Shandong Academy of Medical Sciences

摘要/Abstract

摘要： 肺癌干细胞在肺癌的化疗耐药以及侵袭转移中发挥着重要作用。越来越多的证据表明，微小RNA（miRNA）在肿瘤血管生成、耐药性和转移的调节中扮演着重要角色。鉴于肿瘤干细胞被认为是导致肿瘤复发、转移和化疗耐药的原因之一，因此更好地理解miRNA如何调节肺癌干细胞中的基因表达有助于识别新的肿瘤生物标志物和治疗靶点，并将有助于制定更好的肺癌治疗策略。

关键词: 微RNAs, 肺肿瘤, 肿瘤干细胞

Abstract: Lung cancer stem cells play an important role in chemoresistance and invasion and metastasis of lung cancer. Increasing evidence sustains that microRNAs (miRNAs) play a major role in regulating tumor angiogenesis, drug resistance and metastasis. Cancer stem cells are considered to be one of the reasons leading to cancer recurrence, metastasis and resistance to chemotherapy, therefore better understanding how miRNAs regulate gene expression in lung cancer stem cells will help identify cancer biomarkers and new therapeutic targets, and will help to develop better treatment strategies for lung cancer.

Key words: MicroRNAs, Lung neoplasms, Tumor stem cells

赵国丽1，2,刘恒铫1,张月英2 . 微小RNA在肺癌干细胞中的调控作用[J]. 国际肿瘤学杂志, 2019, 46(4): 231-234.

Zhao Guoli1,2, Liu Hengyao1, Zhang Yueying2. Regulating effect of microRNAs in lung cancer stem cells[J]. Journal of International Oncology, 2019, 46(4): 231-234.

参考文献

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微小RNA在肺癌干细胞中的调控作用

Regulating effect of microRNAs in lung cancer stem cells

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