SNX家族调控肿瘤发生发展的机制

doi:10.3760/cma.j.issn.1673-422X.2018.12.007

摘要/Abstract

摘要： 分选连接蛋白（SNX）家族是一类参与蛋白质分选和转运的功能蛋白，目前在哺乳动物中共发现33个成员参与调节生命活动。SNX家族在多种肿瘤中表达异常，包括结直肠癌、胃癌、肝癌、甲状腺癌、肺癌、乳腺癌、宫颈癌等，并通过分选和转运调控肿瘤活动的关键蛋白，对肿瘤的发生、发展、侵袭、转移、预后及化疗耐药发挥重要作用，为肿瘤的治疗提供了新途径。

关键词: 肿瘤肿瘤, 分选连接蛋白分选连接蛋白

Abstract: The sorting nexin (SNX) family is a class of functional proteins involved in protein sorting and transfer. A total of 33 members are involved in the regulation of life activities in mammal. SNX family expresses abnormally in a variety of tumors, including colorectal cancer, gastric cancer, liver cancer, thyroid cancer, lung cancer, breast cancer, cervical cancer, et al. SNX family plays important roles in tumor genesis, development, invasion, metastasis, prognosis and chemotherapy resistance by sorting and transfer of key proteins regulating tumor activity, and provides a new way for the treatment of tumors.

Key words: Neoplasms, Sorting nexin

胡博，鲁继斌. SNX家族调控肿瘤发生发展的机制[J]. 国际肿瘤学杂志, 2018, 45(12): 735-738.

Hu Bo, Lu Jibin. Regulatory mechanism of SNX family in tumor genesis and development[J]. Journal of International Oncology, 2018, 45(12): 735-738.

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