国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (12): 918-921.doi: 10.3760/cma.j.issn.1673-422X.2017.12.009

• 综述 • 上一篇    下一篇

上皮间质转化的表观遗传调控

李文清,侯劲松   

  1. 510055 广州，中山大学光华口腔医学院附属口腔医院口腔颌面外科 广东省口腔医学重点实验室
  • 出版日期:2017-12-08 发布日期:2017-12-01
  • 通讯作者: 侯劲松，Email: houjs@mail.sysu.edu.cn E-mail:houjs@mail.sysu.edu.cn
  • 基金资助:
    国家自然科学基金（81572660）；广东省自然科学基金（2015A030313034）

Epigenetic regulation of epithelial-mesenchymal transition

Li Wenqing, Hou Jinsong   

  1. Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Online:2017-12-08 Published:2017-12-01
  • Contact: Hou Jinsong, Email: houjs@mail.sysu.edu.cn E-mail:houjs@mail.sysu.edu.cn
  • Supported by:
    National Natural Science Foundation of China (81572660); Natural Science Foundation of Guangdong Province of China (2015A030313034)

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摘要： E-钙黏蛋白（E-cadherin）表达丧失是上皮间质转化(EMT)的重要标志，许多EMT转录因子结合到E-cadherin启动子区下调其表达，从而调节EMT。表观遗传调控包括DNA甲基化、组蛋白修饰、微小RNA，均参与EMT相关基因表达调控。研究表明，EMT转录因子协同表观遗传调控因子参与E-cadherin表达。靶向EMT表观调控代表着肿瘤新的治疗方向。 【关键词】DNA甲基化； 微RNAs； 组蛋白修饰； 上皮间质转化

关键词: DNA甲基化, 微RNAs, 组蛋白修饰, 上皮间质转化

Abstract: The hallmark of epithelial-mesenchymal transition (EMT) is the loss of E-cadherin. The downregulation of E-cadherin can be mediated by its transcriptional repression through the binding of EMT transcription factors to the E-cadherin promoter. Epigenetic mechanisms including DNA methylation, histone code and microRNAs are involved in the regulation of EMT-related genes. Studies have shown that EMT transcription factors can cooperate with several epigenetic modifiers to participate in the expression of E-cadherin. Targeting epigenetic regulation of EMT represents a new promising therapeutic direction.

Key words: DNA methylation, MicroRNAs, Histone code, Epithelial-mesenchymal transition