姜黄素抗食管癌的机制

doi:10.3760/cma.j.issn.1673-422X.2016.05.015

摘要/Abstract

摘要： 姜黄素可通过诱导细胞周期阻滞、阻断Notch信号通路来抑制食管癌细胞增殖，通过抑制核转录因子κB（NFκB）信号通路、抑制食管癌血管生成、抑制基质金属蛋白酶（MMP）来抑制食管癌细胞侵袭，通过核磷蛋白的表达与定位变化来调控食管癌细胞凋亡从而发挥抗食管癌作用。

关键词: 姜黄素, 食管肿瘤

Abstract: Curcumin can suppress the proliferation of esophageal cancer cells by inducing cell cycle arrest and blocking Notch signaling pathway, and can inhibit the invasiveness of esophageal cancer cells by inhibiting the nuclear factorκB (NFκB) signaling pathway and suppressing the formation of tumor blood vessels and inhibiting matrix metalloproteinase (MMP). Curcumin can also regulate apoptosis of esophageal cancer cells by changing the expression and localization of nucleophosmin.

Key words: Curcumin, Esophageal neoplasms

田若楠，孙剑经，张林西. 姜黄素抗食管癌的机制[J]. 国际肿瘤学杂志, 2016, 43(5): 379-381.

Tian Ruonan,Sun Jianjing, Zhang Linxi. Mechanism of curcumin resisting esophageal cancer[J]. Journal of International Oncology, 2016, 43(5): 379-381.

参考文献

［1］ Liao S, Xia J, Chen Z, et al. Inhibitory effect of curcumin on oral carcinoma CAL27 cells via suppression of Notch1 and NFκB signaling pathways［J］. J Cell Biochem, 2011, 112(4): 1055-1065. DOI: 10.1002/jcb.23019. ［2］ Ashworth T, Roy AL. Phase specific functions of the transcription factor TFⅡⅠ during cell cycle［J］. Cell Cycle, 2009, 8(4): 596-605. ［3］ Mendelson J, Song S, Li Y, et al. Dysfunctional transforming growth factorβ signaling with constitutively active Notch signaling in Barrett′s esophageal adenocarcinoma［J］. Cancer, 2011, 117(16): 3691-3702. DOI: 10.1002/cncr.25861. ［4］ Peters JH, Avisar N. The molecular pathogenesis of Barrett′s esophagus: common signaling pathways in embryogenesis metaplasia and neoplasia［J］. J Gastrointest Surg, 2010, 14 Suppl 1: S81-87. DOI: 10.1007/s1160500910117. ［5］ Masuda S. Dysfunctional transforming growth factorβ signaling with constitutively active notch signaling in Barrett′s esophageal adenocarcinoma［J］. Cancer, 2012, 118(7): 1956-1957. DOI: 10.1002/cncr.26444. ［6］ Subramaniam D, Ponnurangam S, Ramamoorthy P, et al. Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling［J］. PLoS One, 2012, 7(2): e30590. DOI: 10.1371/journal.pone.0030590. ［7］ Tian F, Fan T, Zhang Y, et al. Curcumin potentiates the antitumor effects of 5FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NFκB signaling pathway in vitro and in vivo［J］. Acta BiochimBiophys Sin(Shanghai), 2012, 44(10): 847-855. ［8］ Hanahan D,Weinberg RA.Hallmarks of cancer: the next generation［J］. Cell, 2011, 144(5): 646-674. DOI: 10.1016/j.cell.2011.02.013. ［9］ Shehzad A, LeeJ, Lee YS. Curcumin in various cancers［J］. Biofactors, 2013, 39(1): 56-68. DOI: 10.1002/biof.1068. ［10］ Stasinopoulos I, Shah T, Penet MF, et al. Cox2 in cancer: Gordian knot or Achilles heel?［J］. Front Pharmacol, 2013, 4: 34. DOI: 10.3389/fphar.2013.00034. ［11］ Park J, Conteas CN. Anticarcinogenic properties of curcumin on colorectal cancer［J］. World J Gastrointe Oncol, 2010, 2(4): 169-176. DOI: 10.4251/wjgo.v2.i4.169. ［12］ Ye F, Zhang GH, Guan BX, et al. Suppression of esophageal cancer cell growth using curcumin, ()epigallocatechin3gallate and lovastatin［J］. World J Gastroenterol, 2012, 18(2): 126-135. DOI: 10.3748/wjg.v18.i2.126. ［13］ Xu XC. Risk factors and gene expression in esophageal cancer［J］. Methods Mol Biol, 2009, 471: 335-360. DOI: 10.1007/9781597454162_17. ［14］ Mukherjee T, Kumar A, Mathur M, et al. Ets1 and VEGF expression correlates with tumor angiogenesis, lymph node metastasis, and patient survival in esophageal squamous cell carcinoma［J］. J Cancer Res Clin Oncol, 2003, 129(7): 430-436. ［15］ Xiao X, Prasadan K, Guo P, et al.Pancreatic duct cells as a source of VEGF in mice［J］. Diabetologia, 2014, 57(5): 991-1000. DOI: 10.1007/s001250143179y. ［16］ Xiao X, Guo P, Chen Z, et al.Hypoglycemia reduces vascular endothelial growth factor a production by pancreatic beta cells as a regulator of beta cell mass［J］. J Biol Chem, 2013, 288(12): 8636-8646. DOI: 10.1074/jbc.M112.422949. ［17］武志, 潘晓玲, 仲洁. MMP2和MMP9在食管癌中表达的研究［J］. 国际肿瘤学杂志, 2013, 40(9)： 708-711. DOI: 10.3760/cma.j.issn.1673422X.2013.09.022. ［18］ Chen Y, Jiang T, Mao A, et al. Esophageal cancer stem cells express PLGF to increasecancer invasion through MMP9 activation［J］. Tumor Biol, 2014, 35(12): 12749-12755. DOI: 10.1007/s132770142601x. ［19］ Colombo E, Alcalay M, Pelicci PG. Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases［J］. Oncogene, 2011, 30(23): 2595-2609. DOI: 10.1038/onc.2010.646. ［20］ Chiarella S, De Cola A, Scaglione GL, et al. Nucleophosmin mutations alter its nucleolar localization by impairing Gquadruplex binding at ribosomal DNA［J］. Nucleic Acids Res, 2013, 41(5): 3228-3239. DOI: 10.1093/nar/gkt001. ［21］ Shi SL, Liang Y, Li QF, et al. Localization of nucleophosmin in nuclear matrix and changes in its expression during the differentiation of human neuroblastoma induced by retinoic acid［J］. J Cell Biochem, 2010, 111(1): 67-74. DOI: 10.1002/jcb.22663. ［22］ Weng CH, Yung BY, Weng JJ, et al. Involvement of nucleophosmin/B23 in the cellular response to curcumin［J］. J Nutr Biochem, 2011, 22(1): 46-52. DOI: 10.1016/j.jnutbio.2009.11.010.

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