国际肿瘤学杂志

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (5): 308-311.doi: 10.3760/cma.j.issn.1673422X.2018.05.013

• 综述 • 上一篇    下一篇

环状RNA及其在妇科肿瘤中的应用

郑盼婵,孙笑,王丽华    

  1. 200030 上海交通大学医学院附属国际和平妇幼保健院妇科肿瘤科   
  • 出版日期:2018-05-08 发布日期:2018-05-23
  • 通讯作者: 王丽华,Email: drwanglh0420@163.com E-mail:drwanglh0420@163.com
  • 基金资助:

    国家自然科学基金(81572547)

Circular RNA and its application in gynecological carcinoma

Zheng Panchan, Sun Xiao, Wang Lihua   

  1. Department of Gynecologic Oncology, the International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2018-05-08 Published:2018-05-23
  • Contact: Wang Lihua E-mail:drwanglh0420@163.com
  • Supported by:

    National Natural Science Foundation of China (81572547)

PDF

420

摘要： 环状RNA是一种共价闭合环状分子，在环状RNA微小RNA信使RNA调控轴中充当微小RNA的海绵作用，可调控基因转录及蛋白质翻译。在妇科肿瘤中，环状RNA存在差异性表达，可影响细胞的增殖、迁移、侵袭，从而发挥抑癌或促癌作用。环状RNA的稳定性、丰富性、特异性及保守性使其有望成为妇科肿瘤预测、诊断及治疗的新靶点。

关键词: 微RNAs, 生殖器肿瘤, 女(雌)性, 基因表达调控, 环状RNA

Abstract: Circular RNAs (circRNAs) are a class of RNA which forms covalently closed loops. They act as microRNA (miRNA) sponge in the circRNAmiRNAmRNA regulatory axis, regulating gene transcription and protein translation. CircRNAs are differently expressed in gynecological carcinoma. They can affect the proliferation, invasion and migration of gynecological tumor cells, playing a role in inhibiting or promoting cancer. CircRNAs are featured with characteristics of  stabilities, abundance, specificity  and conservative, making it a potential target  for the prediction, diagnosis and treatment of gynecologic tumors.

Key words: MicroRNAs, Genital neoplasms, female, Gene expression regulation, Circular RNA