淋巴细胞减少诱导的T细胞稳态增殖在抗肿瘤免疫治疗中的研究

doi:10.3760/cma.j.issn.1673422X.2018.02.009

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (2): 100-102.doi: 10.3760/cma.j.issn.1673422X.2018.02.009

淋巴细胞减少诱导的T细胞稳态增殖在抗肿瘤免疫治疗中的研究

赖楠,陈泽宏,杨子科,刘严友葓,康世均

510315广州，南方医科大学中西医结合医院肿瘤中心（赖楠、陈泽宏、杨子科）；南方医科大学南方医院肿瘤科（刘严友葓、康世均）

出版日期:2018-02-08 发布日期:2018-02-28
通讯作者: 康世均，Email： junekfm@yahoo.com E-mail:junekfm@yahoo.com
基金资助:
国家自然科学基金（81372449）

Research progresses of lymphopenia induced T cell homeostatic proliferation in antitumor immunity

Lai Nan, Chen Zehong, Yang Zike, Liu Yanyouhong, Kang Shijun

Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, China

Online:2018-02-08 Published:2018-02-28
Contact: Kang Shijun E-mail:junekfm@yahoo.com
Supported by:
National Natural Science Foundation of China（81372449）

摘要/Abstract

摘要： 机体在一定程度上能维持自身T细胞数量的稳定。淋巴细胞减少诱导的T细胞的稳态增殖由于缺少外来抗原及炎性因子的刺激，能重新识别包括肿瘤抗原在内的自身抗原。这一过程能打破原有免疫耐受状态，并产生抗肿瘤免疫效应。稳态增殖过程中会产生一些负性免疫分子的募集，削弱稳态增殖在抗肿瘤免疫中的作用。

关键词: 细胞增殖, 淋巴细胞减少, 免疫耐受

Abstract: Generally speaking, the organism can maintain the stability of T cells. The lymphopeniainduced homeostatic proliferation of T cells could be driven by the recognition of autoantigen including tumor antigen in the absence of foreign antigens or inflammatory signals. This process can break tumorinduced immune tolerance and induce a powerful antitumor immunity. It is confirmed that some negative immune molecules are recruited during the homeostatic proliferation, then the antitumor immunity will be impaired.

Key words: Cell proliferation, Lymphopenia, Immune tolerance

赖楠, 陈泽宏, 杨子科, 刘严友葓, 康世均. 淋巴细胞减少诱导的T细胞稳态增殖在抗肿瘤免疫治疗中的研究[J]. 国际肿瘤学杂志, 2018, 45(2): 100-102.

LAI Nan, CHEN Ze-Hong, YANG Zi-Ke, LIU Yan-You-Hong, KANG Shi-Jun. Research progresses of lymphopenia induced T cell homeostatic proliferation in antitumor immunity[J]. Journal of International Oncology, 2018, 45(2): 100-102.

参考文献

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淋巴细胞减少诱导的T细胞稳态增殖在抗肿瘤免疫治疗中的研究

Research progresses of lymphopenia induced T cell homeostatic proliferation in antitumor immunity

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