NF-κB信号转导通路对神经胶质瘤生物学特性的影响及机制

doi:10.3760/cma.j.issn.1673422X.2016.12.011

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (12): 924-926.doi: 10.3760/cma.j.issn.1673422X.2016.12.011

NF-κB信号转导通路对神经胶质瘤生物学特性的影响及机制

刘静, 吴勇强, 郭庚, 王小刚

山西医科大学第一医院神经外科

出版日期:2016-12-08 发布日期:2016-11-02
基金资助:
国家自然科学基金（81201991）；中国博士后科学基金（2015M571068、2016T90115）；北京市博士后工作经费资助项目（2015ZZ56、2016ZZ43）；山西省自然科学基金（201601D011127）；山西省高等学校创新人才支持计划（晋教科［2013］8号）；山西省卫生厅科研课题（201301066）

Effect and mechanism of NF-κB signaling pathway on the biological characteristics of glioma

LIU Jing, WU Yong-Qiang, GUO Geng, WANG Xiao-Gang

Department of Neurosurgery, First Hospital, Shanxi Medical University, Taiyuan 030001, China

Online:2016-12-08 Published:2016-11-02
Supported by:
National Natural Science Foundation of China (81201991)； China Postdoctoral Science Foundation (2015M571068, 2016T90115)；Project Supported by Beijing Postdoctoral Research Foundation (2015ZZ56, 2016ZZ43); Natural Science Foundation of Shanxi Province of China (201601D011127)； Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi Province(20138); Scientific Research Subject of Shanxi Provincial Health Department (201301066)

摘要/Abstract

摘要： 核转录因子-κB（NF-κB）信号转导通路广泛存在于真核生物中，参与胚胎发育、炎症、免疫以及肿瘤的发生发展等多种生物进程。NFκB信号转导通路的异常激活与神经胶质瘤的生物学特性改变密切相关。研究NFκB信号转导通路与胶质瘤增殖、侵袭、凋亡和血管新生的关系，将为神经胶质瘤的治疗提供新的思路和靶点。

关键词: 神经胶质瘤, NF-κB, 信号传导

Abstract: NF-κB signaling pathway is widely present in eukaryotes, and it is involved in many biological processes, such as embryonic development, inflammation, immunity, and tumor development. The abnormal activation of NFκB signaling pathway is closely related to the biological characteristics of glioma. Investigating the role of NFκB signaling pathway in the glioma proliferation, invasion, apoptosis and angiogenesis will provide new ideas and targets for the treatment of glioma.

Key words: Glioma, NF-kappa B, Signal transduction

刘静, 吴勇强, 郭庚, 王小刚. NF-κB信号转导通路对神经胶质瘤生物学特性的影响及机制[J]. 国际肿瘤学杂志, 2016, 43(12): 924-926.

LIU Jing, WU Yong-Qiang, GUO Geng, WANG Xiao-Gang. Effect and mechanism of NF-κB signaling pathway on the biological characteristics of glioma[J]. Journal of International Oncology, 2016, 43(12): 924-926.

参考文献

［1］ Baldwin AS. Regulation of cell death and autophagy by IKK and NFκB: critical mechanisms in immune function and cancer［J］. Immunol Rev, 2012, 246(1): 327345. DOI: 10.1111/j.1600065X.2012.01095.x. ［2］ Lu T, Stark GR. NFκB: regulation by methylation［J］. Cancer Res, 2015, 75(18): 36923695. DOI: 10.1158/00085472.CAN151022. ［3］ Li F, Zhang J, Arfuso F, et al. NFκB in cancer therapy［J］. Arch Toxicol, 2015, 89(5): 711731. DOI: 10.1007/s0020401514704. ［4］ Tchoghandjian A, Jennewein C, Eckhardt I, et al. Identification of noncanonical NFκB signaling as a critical mediator of Smac mimeticstimulated migration and invasion of glioblastoma cells［J］. Cell Death Dis, 2013, 4: e564. DOI: 10.1038/cddis.2013.70. ［5］杜正云, 肖宝荣, 翟西菊. 核因子κB与肿瘤放射治疗［J］. 国际肿瘤学杂志, 2014, 41(7): 503507. DOI: 10.3760/cma.j.issn.1673422X.2014.07.007. ［6］ Taylor LP. Diagnosis, treatment, and prognosis of glioma: five new things［J］. Neurology, 2010, 75(18 Suppl 1): S28S32. DOI: 10.1212/WNL.0b013e3181fb3661. ［7］ Cahill KE, Morshed RA, Yamini B. Nuclear factorκB in glioblastoma: insights into regulators and targeted therapy［J］. Neuro Oncol, 2016, 18(3): 329339. DOI: 10.1093/neuonc/nov265. ［8］ Lee DW, Ramakrishnan D, Valenta J, et al. The NFκB RelB protein is an oncogenic driver of mesenchymal glioma［J］. PLoS One, 2013, 8(2): e57489. DOI: 10.1371/journal.pone.0057489. ［9］ Li H, Chen L, Zhang A, et al. Silencing of IKKε using siRNA inhibits proliferation and invasion of glioma cells in vitro and in vivo［J］. Int J Oncol, 2012, 41(1): 169178. DOI: 10.3892/ijo.2012.1452. ［10］ Liu J, Liu Y, Ren Y, et al. Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factorκB signaling pathway［J］. Mol Med Rep, 2014, 9(3): 10681074. DOI: 10.3892/mmr.2014.1888. ［11］ Meng Q, Zhi T, Chao Y, et al. Bex2 controls proliferation of human glioblastoma cells through NFκB signaling pathway［J］. J Mol Neurosci, 2014, 53(2): 262270. DOI: 10.1007/s1203101302151. ［12］ Yang TQ, Lu XJ, Wu TF, et al. MicroRNA16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factorκB1/MMP9 signaling pathway［J］. Cancer Sci, 2014, 105(3): 265271. DOI: 10.1111/cas.12351. ［13］ Yang G, Han D, Chen X, et al. MiR196a exerts its oncogenic effect in glioblastoma multiforme by inhibition of IκBα both in vitro and in vivo［J］. Neuro Oncol, 2014, 16(5): 652661. DOI: 10.1093/neuonc/not307. ［14］ Xia W, Fu W, Cai X, et al. Angiogenin promotes U87MG cell proliferation by activating NFκB signaling pathway and downregulating its binding partner FHL3［J］. PLoS One, 2015, 10(2): e0116983. DOI: 10.1371/journal.pone.0116983. ［15］ Munson J, Bonner M, Fried L, et al. Identifying new small molecule antiinvasive compounds for glioma treatment［J］. Cell Cycle, 2013, 12(14): 22002209. DOI: 10.4161/cc.25334. ［16］ Sun P, Mu Y, Zhang S. A novel NFκB/MMP3 signal pathway involves in the aggressivity of glioma promoted by Bmi1［J］. Tumour Biol, 2014, 35(12): 1272112727. DOI: 10.1007/s1327701425972. ［17］ Hwang SK, Baker AR, Young MR, et al. Tumor suppressor PDCD4 inhibits NFκBdependent transcription in human glioblastoma cells by direct interaction with p65［J］. Carcinogenesis, 2014, 35(7): 14691480. DOI: 10.1093/carcin/bgu008. ［18］ Kesanakurti D, Chetty C, Rajasekhar Maddirela D, et al. Essential role of cooperative NFκB and Stat3 recruitment to ICAM1 intronic consensus elements in the regulation of radiationinduced invasion and migration in glioma［J］. Oncogene, 2013, 32(43): 51445155. DOI: 10.1038/onc.2012.546. ［19］ Vriend J, Reiter RJ. Melatonin as a proteasome inhibitor. Is there any clinical evidence?［J］. Life Sci, 2014, 115(1/2): 814. DOI: 10.1016/j.Ifs.2014.08.024. ［20］ Peng Z, Shuangzhu Y, Yongjie J, et al. TNF receptorassociated factor 6 regulates proliferation, apoptosis, and invasion of glioma cells［J］. Mol Cell Biochem, 2013, 377(1/2): 8796. DOI: 10.1007/s1101001315732. ［21］ Xie TX, Xia Z, Zhang N, et al. Constitutive NFkappaB activity regulates the expression of VEGF and IL8 and tumor angiogenesis of human glioblastoma［J］. Oncol Rep, 2010, 23(3): 725732. DOI: 10.3892/or_00000690. ［22］ Garkavtsev I, Kozin SV, Chernova O, et al. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis［J］. Nature, 2004, 428(6980): 328332. DOI: 10.1038/nature02329. ［23］ Jiang L, Song L, Wu J, et al. Bmi1 promotes glioma angiogenesis by activating NFκB signaling［J］. PLoS One, 2013, 8(1): e55527. DOI: 10.1371/journal.pone.0055527.

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NF-κB信号转导通路对神经胶质瘤生物学特性的影响及机制

Effect and mechanism of NF-κB signaling pathway on the biological characteristics of glioma

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