国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (5): 324-326.doi: 10.3760/cma.j.issn.1673422X.2015.05.002

• 论著 • 上一篇    下一篇

HBsAg携带及肝癌家族史与原发性肝癌发病年龄的相关性分析

  

  1. 江苏省启东肝癌防治研究所病因室
  • 出版日期:2015-05-08 发布日期:2015-05-12
  • 通讯作者: 陈陶阳 ty110@263.net
  • 基金资助:

    国家科技重大专项(2008ZX10002018、2012ZX10002010001)

Analysis of association of hepatitis B virus infection and family history of hepatocellular carcinoma with age at primary liver cancer

  1. Department of Etiology, Qidong Liver Cancer Institute of Jiangsu Province
  • Online:2015-05-08 Published:2015-05-12
  • Contact: Chen Taoyang ty110@263.net

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被引次数

5

摘要： 目的 探讨乙型肝炎病毒表面抗原（HBsAg）携带及肝癌家族史与高发区原发性肝癌发病年龄的关系。方法 以1 359例启东籍原发性肝癌住院病例为研究对象，分析HBsAg携带及肝癌家族史与发病年龄的相关性及相互间的协同作用。结果 肝癌患者中男性1 053例，女性306例，发病年龄20～84岁，平均(54.02±10.47)岁。HBsAg阳性肝癌平均发病年龄比HBsAg阴性肝癌提前9.24岁（51.99岁∶61.23岁，t=13.51，P=0.000）；有肝癌家族史肝癌比无肝癌家族史肝癌提前2.70岁（52.53岁∶55.23岁，t=4.839，P=0.000），差异均有统计学意义。HBsAg阳性肝癌中，平均发病年龄男性低于女性（51.18岁∶54.89岁，t=5.353，P=0.000），有家族史患者低于无家族史患者（51.33 岁∶52.62岁，t=2.233，P=0.026）；HBsAg阴性肝癌中，虽然平均发病年龄男性与女性相比（60.83岁∶62.45岁）、有家族史与无家族史相比（59.58岁∶61.92岁）都有所提前，但差异均无统计学意义（t=1.126，P=0.261；t=1.728，P=0.085）。结论 启东地区HBsAg携带使原发性肝癌平均发病年龄显著提前。性别和肝癌家族史在HBsAg阳性肝癌中与发病年龄密切相关，在HBsAg阴性肝癌中对发病年龄影响不显著。

关键词: 肝肿瘤/肝炎表面抗原, 乙型/发病年龄/家族史, 肝癌

Abstract: ObjectiveTo explore the relationship of hepatitis B virus surface antigen (HBsAg) infection and family history of hepatocellular carcinoma (HCC) with age at primary liver cancer. MethodsTotally 1 359 cases of primary liver cancer were enrolled. Their data of sex, HBsAg status and family history informations of liver cancer were analyzed on the associations with diagnosis age. ResultsOf the 1 359 cases, 1 053 were males and 306 were females, their average age at diagnosis was (54.02±10.47) years (2084 years). For HBsAg positive cases, the average age at diagnosis was 51.99, significantly younger than that of HBsAg negative cases （61.23）, t=13.51, P=0.000. Cases with family history of HCC were diagnosed at a significantly earlier age than those without family history （52.53 vs 55.23, t=4.389, P=0.000）. In HBsAg positive cases, the average age at diagnosis showed a significant difference not only between males and females (51.18 vs 54.89, t=5.353, P=0.000), but also between cases with family history and cases without family history (51.33 vs 52.62, t=2.233, P=0.026). In HBsAg negative cases, the average age at diagnosis of males and females were 60.83 and 62.45 respectively (t=1.126, P=0.261). The average age at diagnosis of cases with family history and cases without family history were 59.58 and 61.92 respectively (t=1.728, P=0.085), both showed no significant difference. ConclusionCases of primary liver cancer with positiveHBsAg are diagnosed averagely 9.24 years younger than those with negativeHBsAg in Qidong. Sex and family history of HCC significantly advance hepatocarcinogenesis only in HBsAg positive individuals, not in HBsAg negative individuals.