Journal of International Oncology ›› 2015, Vol. 42 ›› Issue (7): 548-550.doi: 10.3760/cma.j.issn.1673-422X.2015.07.020

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Research progress of transcription factor AP-2 in urogenital cancer

Xie Yu, Fan Gang, Zhang Jian   

  1. Key Laboratory of Protein Chemistry and Developmental Biology of State Education Ministry of China, College of Life Sciences, Hunan Normal University; Department of Urology, Hunan Provincial Tumor Hospital, Affiliated Cancer Hospital of Xiangya Medical College, Central South University, Changsha 410081, China
  • Online:2015-07-08 Published:2015-05-26
  • Contact: Zhang Jian E-mail:zhangjian@hunnu.edu.cn

Abstract: Transcription factor activator protein2 (AP2) plays an important role in the cancer cell proliferation, differentiation, carcinogenesis and chemotherapy resistance. The effects of AP2 in different urogenital cancers are complex, sometimes acting as cancersuppressor, sometimes as cancerpromoter. Researches on the roles and mechanisms of AP2 in urogenital cancers can provide new ideas and directions for the cancer diagnosis and therapy.

Key words: Transcription factor AP-2, Urogenital neoplasms