Abstract: SiRNA comes from doublestranded RNA, which is processed into a small molecular fragment by Dicer. 2125nt siRNA, as the key effector molecules to the RNAi process, can inhibit gene expression with high specificity and high efficiency in mammalian cells. Currently, RNAi has been widely applied in a variety of cancer. RNAi has many active research explorations of the tumor development, metastasis and treatment in gastrointestinal cancer.

Key words: RNA, small interfering, RNA interference, Gastrointestinal neoplasms