Research progress of oncolytic viruses in reversing tumor immune therapy resistance

doi:10.3760/cma.j.cn371439-20250727-00060

Abstract

Abstract:

Oncolytic viruses， as an innovative therapy with multiple anti-tumor mechanisms， have shown significant potential in reversing immune therapy resistance. Research on the technological evolution of oncolytic viruses indicates that they gradually overcome tumor drug resistance through mechanism innovation. In the field of tumor immunotherapy， oncolytic virus therapy is undergoing significant technological advancements. It has evolved from early virus selective replication to gene-engineered vectors capable of carrying multiple immune regulatory factors， which can reverse immune therapy resistance. In terms of clinical translation and application， both monotherapy and combination therapy have demonstrated good therapeutic potential. Exploring the synergistic mechanisms of oncolytic virus combination therapy and analyzing the challenges and future development directions in clinical translation can provide new ideas for overcoming tumor immune resistance.

Key words: Oncolytic virotherapy, Immunotherapy, Drug resistance， neoplasm, Nanoparticles

Gao Yuqiong, Diao Jie, Yin Hong. Research progress of oncolytic viruses in reversing tumor immune therapy resistance[J]. Journal of International Oncology, 2026, 53(7): 434-438.

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