Journal of International Oncology

Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (3): 176-179.

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Function of securin and its research advances in tumor

GUO  Hong-Yan, JIN  Hui-Qin, ZHANG  Yun-Fei, ZHANG  Xu   

  1. Department of Pathology, Second People’s Hospital of Gansu, Lanzhou 730000, China
  • Online:2012-03-08 Published:2012-02-24

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Abstract: Securin is a multifunctional protein which is encoded by pituitary tumor-transforming gene. In the metaphase to anaphase transition during mitosis, securin is involved in sister chromatid separation. The aberrant expression of securin is found in many endocrine glands and related cancers, such as pituitary tomour, thyroid cancer, ovarian cancer, colon cancer and so on. The function of securin in cancer is related to its gene transactivation and association with other poteins like p21, p53.

Key words: color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt">Neoplasms, color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt">Securin