Thioredoxin and neoplasm metastasis

Journal of International Oncology ›› 2012, Vol. 39 ›› Issue (2): 86-88.

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Thioredoxin and neoplasm metastasis

ZHANG Ti, LI Hui-Kai, LI Qiang

Department of Hepatobiliary Surgery, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China

Online:2012-02-08 Published:2012-01-18
Contact: Corresponding author: LI Qiang, E-mail: liqiang4016@yahoo.com E-mail:liqiang4016@yahoo.com

Abstract

Abstract: Thioredoxin (Trx) is a class of small redox proteins which is widely found in all organisms. It acts as antioxidant by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange. Recently, thioredoxin is found to be over-expressed in many kinds of tumor, which is closely associated with tumor cell proliferation, apoptosis and cell cycle control. Trx is also found to promote the synthesis and stabilization of the HIF-1α protein. It is also related to the control of reactive oxygen species and chemoresistance of tumor cells. Trx has been proved to play an important role in promoting the metastasis of cancer, and may become a potential target for anti-metastasis of cancer.

ZHANG Ti, LI Hui-Kai, LI Qiang. Thioredoxin and neoplasm metastasis[J]. Journal of International Oncology, 2012, 39(2): 86-88.

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